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确定临床细菌分离物的西塔弗洛克萨流行病学截止值 (ECOFFs)

Jingjia Zhang^1,2, Xue Li¹, Xinmiao Jia³

¹Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.

Infection and drug resistance

|April 28, 2025

概括

本研究确定了针对九种关键细菌病原体的西塔素的流行病学切断值 (ECOFFs). 这些ECOFF对于解释抗菌素敏感性测试结果和监测耐药性趋势至关重要.

科学领域:

微生物学微生物学
抗微生物耐药性抗微生物耐药性
药理学药理学是指药理学的学科.

背景情况:

抗菌素耐药性是一个日益增长的全球健康威胁.
西塔弗洛克萨是一种具有广谱活性的诺基诺隆抗生素.
确定流行病学切线值 (ECOFF) 对于准确的敏感性测试至关重要.

研究的目的:

为了确定Sitafloxacin的最小抑制度 (MIC) 和区域直径的ECOFFs.
为了评估西塔弗洛克萨对常见的临床细菌分离物的活性.
为了提供对西塔弗洛克萨抗菌敏感性测试的参考值.

主要方法:

从中国收集了2264种临床细菌分离物.
使用汁微稀释确定MIC和使用磁盘扩散确定区域直径 (EUCAST指南).
使用了ECOFFinder软件和用于ECOFF测定的视觉估计;用于抗性机制分析的全基因组测序.

主要成果:

西塔弗洛克萨辛的MIC在物种之间有所不同,从0.002到64毫克/升不等.
已建立的MIC ECOFFs是针对大肠杆菌,肺炎,P. aeruginosa,A. baumannii,S. aureus,E. faecalis,E. faecium和S. pneumoniae的.
已建立的区域直径ECOFFs为八种物种,与MIC有很高的相关性,除了*S. pneumoniae*.

结论:

成功建立了针对九种细菌物种的西塔弗洛克萨辛的MIC和区域直径ECOFF.
对于 * Proteus mirabilis * 的 MIC ECOFF 是暂时的.
区域直径和MIC之间的相关性不足,阻止了ECOFF对*Streptococcus pneumoniae*的*区域直径的建立.

关键词:

这就是为什么B.M.D. BMD.经济合作基金 (ECOFF) 是一个.在MIC中,MIC是MIC,MIC是MIC.磁盘扩散是指光盘的扩散.这种药物是Sitafloxacin.区域直径区域直径区域直径

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