在胃癌中,Helicobacter pylori感染和编程死亡对象1之间的关系:元分析
Hong-Chang Yang1, Cheng-Feng Fu2, Li-Jun Qiao3
1Department of Gastroenterology, Longgang Central Hospital of Shenzhen, Shenzhen 518100, Guangdong Province, China.
World journal of clinical oncology
|April 28, 2025
概括
杆菌感染与胃癌 (GC) 中更高的编程死亡配体1 (PD-L1) 表达有关. 这一发现表明,H. pylori的状态可能会影响PD-L1向治疗的有效性.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 胃癌 (GC) 是全球流行的一种恶性瘤.
- 杆菌 (HP) 感染是已知的GC发展的危险因素.
- 编程死亡配体1 (PD-L1) 表达是预测免疫检查点抑制剂反应的关键生物标志物.
研究的目的:
- 在胃癌患者中进行元分析,评估HP感染与PD-L1表达之间的关联.
- 为了澄清先前关于GC中HP和PD-L1的研究中的相互矛盾的结果.
主要方法:
- 对PubMed,Embase,Cochrane图书馆和Web of Science数据库进行系统的文献审查.
- 在GC中包括检查HP感染和PD-L1表达的观察性研究.
- 由于异质性,使用随机效应模型计算聚合赔率比率和95%置信区间.
主要成果:
- 分析了与3069名GC患者的14项研究.
- 在HP感染和GC组织中增加PD-L1表达之间发现了显著的关联 (OR = 1.69,P < 0.001).
- 敏感性和子组分析证实了不同地区和方法的研究结果的稳定性.
结论:
- 肝炎感染与胃癌中PD-L1表达升高显著相关.
- 这种关联表明,HP状态可能是影响患者对PD-1/PD-L1阻断疗法的反应的一个因素.
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