在癌症患者中对功能评估与内部医学的全球实践进行调整
Geeta Sandhu1,2,3, Josephine Adattini2, Evangeline Armstrong Gordon2
1Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
EClinicalMedicine
|April 28, 2025
概括
新的抗癌药物剂量在功能障碍 (ADDIKD) 准则标准化功能评估癌症患者. 它澄清了使用测量的膜过率 (GFR) 和估计的GFR (eGFR) 超过肌素清除,以获得最佳的抗癌药物剂量.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 病:改善全球结果 (KDIGO) 指南提供了一种标准化的功能评估和分类方法.
- 虽然KDIGO指导方针在内部医学中得到广泛采用,但尚未完全融入癌症医学中.
- 癌症专家经常依赖可克克罗夫特-高尔特方程来确定肌素清除率,这与KDIGO的基于GFR的方法有所不同.
研究的目的:
- 制定关于在功能障碍中服用抗癌药物的国际共识指南 (ADDIKD).
- 为应对应用KDIGO建议在癌症患者护理中的挑战.
- 建立一个标准化的,当代的方法来评估和分类脏功能在瘤学.
主要方法:
- 两个虚拟,国际,多学科的共识建设研讨会进行.
- 参与者包括癌症临床医生,病学家和临床药理学家.
- 在标准化功能评估,分类和抗癌药物剂量方面达成了共识.
主要成果:
- 关于基于KDIGO原则为癌症护理的三个核心建议的协议.
- 关于最佳使用测量膜过率 (GFR) 和估计的GFR (eGFR) 而不是肌素清除率的澄清.
- 解决了癌症专家关于从肌素清除过渡到基于GFR的估计的担忧.
结论:
- ADDIKD指南为癌症患者的功能评估提供了一个标准化的框架.
- 它将癌症治疗与其他医学专业所使用的国际标准协调一致.
- 在功能受损的患者中促进最佳的抗癌药物剂量.
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