在高海拔地区通过细菌疗法改善了氧和和适应
James J Yu1, Esteban A Moya1, Hunter Cheng1
1Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
iScience
|April 28, 2025
概括
益生菌可以改善高海拔的适应. 一项研究发现,服用益生菌的参与者氧和度更好,高海拔地区急性山病症状更少.
科学领域:
- 生理学 生理学 生理学
- 微生物学 微生物学
- 高度医学 高度医学
背景情况:
- 由于氧气可用性减少,高海拔带来了生理挑战.
- 改善适应高海拔地区的有效策略有限.
- 益生菌,有益的微生物,正在探索各种健康益处.
研究的目的:
- 研究一种多菌株益生菌在增强适应高海拔地区的疗效.
- 评估益生菌对高度暴露的关键生理标志物的影响.
主要方法:
- 这是一项随机,双盲,安慰剂控制的研究,涉及17名参与者,距离3800米.
- 主要结局:白天和夜晚的氧和度 (SpO2).
- 二级结局:急性山病 (AMS) 评分,睡眠,通风,心率,血压,心率变化和葡萄糖水平.
主要成果:
- 与安慰剂组相比,益生菌组在白天和夜间SPO2显著增加.
- 接受益生菌的参与者报告AMS得分较低,表明疾病严重程度降低.
- 在益生菌组中观察到增强的适应,由改善的SpO2和减少的AMS证明.
结论:
- 多菌株益生菌可以作为一种新的非侵入性干预措施,以改善高海拔适应.
- 细菌疗法为减轻高海拔地区的生理压力提供了潜在的新途径.
- 需要进一步的研究来探索益生菌在高度适应中的机制和长期影响.
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