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来自海绵衍生的真菌Aspergillus versicolor的四种新型Pyranones
Na Zhang1, Jiali Wang1, Jigang Jiang1
1College of Pharmacy, Binzhou Medical University, Yantai 264003, China.
ACS omega
|April 28, 2025
概括
海洋真菌产生了四种新的pyranone衍生物. 化合物2对肺癌细胞有轻微的细胞毒性和中度的DPPH自由基清除活性,表现优于其他新型化合物.
科学领域:
- 海洋天然产品 化学 化学
- 的二次代谢物 的二次代谢物
- 药用化学 医学化学
背景情况:
- 海洋海绵是新型生物活性化合物的丰富来源.
- 与海洋生物相关的真菌可以产生独特的化学结构.
- 皮拉衍生物是众所周知的多种生物活动.
研究的目的:
- 从与海洋海绵 *Aspergillus versicolor* 相关的真菌中分离和鉴定新型的pyranone衍生物.
- 评估分离化合物的细胞毒性和抗氧化活性.
主要方法:
- 使用色谱技术分离化合物.
- 通过高分辨率电子喷雾电离质谱法 (HRESIMS),紫外线,红外线和1D/2D核磁共振 (NMR) 光谱法阐明结构.
- 使用X射线衍射和电子循环二元化 (ECD) 光谱学确定绝对配置.
- 对人类肺癌 (A549) 细胞的细胞毒性测定.
- DPPH自由基清除试验. 检测方法.
主要成果:
- 四种新的pyranone衍生物被成功分离和表征.
- 化合物2对A549细胞表现出中度的细胞毒性活动 (46%的抑制) 和优越的DPPH自由基清除能力 (21.5%的清除率) 在孤立的化合物中.
- 其他化合物与阳性对照 (分别是多克索鲁比和维生素C) 相比显示出有限的细胞毒性和抗氧化活性.
结论:
- 该研究成功地从与海洋相关的真菌中确定了新的pyranone衍生物.
- 化合物2显示出在抗癌和抗氧化剂研究中进一步调查的潜力.
- 这项研究突出了海洋衍生真菌作为生物活性天然产品来源的潜力.
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