奥兰沙平能够在洛拉提尼布诱导的精神病后重新挑战:一个案例报告
Akiyoshi Yokode1, Masaki Fujiwara1, Yuko Nakamura1
1Department of Neuropsychiatry Okayama University Hospital Okayama Japan.
PCN reports : psychiatry and clinical neurosciences
|April 28, 2025
概括
在阿纳普拉斯性淋巴瘤激酶阳性非小细胞肺癌患者中,洛拉提尼布诱导的精神病可以用奥兰扎宾治疗. 这一案例表明,在精神病解消后,洛拉提尼布重新挑战成功,保持癌症控制.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
背景情况:
- 洛拉提尼布是一种第三代氨酸激酶抑制剂,用于治疗形淋巴瘤激酶 (ALK) 阳性非小细胞肺癌 (NSCLC).
- 虽然对内病变有效,但洛拉提尼布可以导致中枢神经系统并发症,包括精神病.
- 管理这些不良事件对于保持癌症治疗疗效至关重要.
研究的目的:
- 在患有ALK阳性NSCLC和大脑转移的患者中呈现洛拉提尼布诱导的精神病例.
- 为了说明洛拉提尼布诱导的精神病与奥兰扎平的成功管理.
- 为了证明洛拉提尼布的可行性,在精神病解决后重新挑战.
主要方法:
- 一名患有ALK阳性NSCLC和大脑转移的32岁女性接受了洛拉提尼布治疗.
- 患者出现了幻觉和妄想,最初接受了RISPERIDONE治疗,但没有完全解决.
- 洛拉提尼布停用后精神病消失;在洛拉提尼布再试之前,奥兰沙平被替换为Risperidone.
主要成果:
- 洛拉提尼布与奥兰扎的再试验是成功的,没有精神症状的复发.
- 持续的洛拉提尼布治疗是可以的,没有观察到肺癌的进展.
- 这种方法允许持续管理大脑转移.
结论:
- 洛拉提尼布对于控制ALK阳性NSCLC中大脑转移至关重要.
- 精神病症状是洛拉提尼布的潜在副作用,需要谨慎管理.
- 瘤学家和精神病学家之间的多学科合作对于管理与癌症治疗相关的不良影响至关重要.
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