再生氧化纤维素作为密封剂和粘合剂在内镜内骨基底重建中的内镜内骨基底重建
Ashwin Gajendran Vedhapoodi1, Aravind Sabesan2, Benazir Ferozkhan1
1Department of Otorhinolaryngology, Head and Neck Surgery, Government Stanley Medical College, Chennai, Tamil Nadu, India.
International archives of otorhinolaryngology
|April 28, 2025
概括
再生氧化纤维素 (ROC) 与内镜内外科手术后头骨基重建的纤维素相比,具有优越的密封剂和粘合性能,减少脑脊液泄漏率.
科学领域:
- 神经外科 神经外科
- 生物材料是一种生物材料.
- 手术创新 在外科创新.
背景情况:
- 内镜内外科手术需要有效的密封剂和粘合剂进行重建,以防止脑脊液 (CSF) 泄漏.
- 纤维素是当前的标准,但其长期有效性和粘合性是需要改进的领域.
- 在这种情况下,再生氧化纤维素 (ROC) 作为密封剂和粘合剂的潜力尚未得到广泛研究.
研究的目的:
- 评估再生氧化纤维素 (ROC) 作为组织密封剂和粘合剂的有效性.
- 为了比较ROC与纤维素在内镜内外科手术期间重建头骨底部缺陷的性能.
- 评估这些药物对术后脑脊液 (CSF) 泄漏率的影响.
主要方法:
- 追溯分析64名接受内镜内皮骨基手术的患者,有缺陷和手术内CSF泄漏.
- 根据使用的密封剂和粘合剂审查了患者的记录:单独使用纤维素,单独使用ROC或组合使用.
- 对手术后的脑脊髓泄漏率进行了分析,与使用的不同密封剂和粘合剂相关.
主要成果:
- 纤维素单独显示出一个高的初始CSF泄漏率 (66.6%).
- 当单独使用时,ROC显示低CSF泄漏率 (8.3%).
- 使用纤维素和ROC的联合治疗也产生了较低的CSF泄漏率 (7.6%),明显低于单独使用纤维素.
结论:
- 虽然纤维素提供了立即的防水密封,再生氧化纤维素 (ROC) 呈现出优越的手术内和长期密封剂和粘合能力.
- ROC是一种有希望的替代品或辅助,可以提高骨基重建的完整性,并减少脑脊液泄漏的发生率.
- 需要进一步研究ROC在内镜内皮骨基手术中的应用.
更多相关视频
12:22Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
Published on: October 26, 2016
11.7K
09:49Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering
Published on: February 23, 2024
1.5K
相关概念视频
01:40Bone Remodeling
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
01:18The Bone Matrix
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
01:27Fractures: Bone Repair
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
01:31Essential Minerals for Bone Health
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...