在北非慢性乙型肝炎患者中评估亚最大有氧能力:试点病例控制研究
Jihene Bergaoui1, Imed Latiri1, Sawssen Mrad2
1Hospital Farhat HACHED, Research laboratory "Heart Failure, LR12SP09, Universite de Sousse Faculte de Medecine de Sousse, Sousse, Sousse, 4000, Tunisia.
F1000Research
|April 28, 2025
概括
与健康个体相比,慢性乙型肝炎 (CHB) 患者的有氧能力降低,衰老加速. 这表明CHB会影响身体健康和心肺呼吸系统健康.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 运动生理学 运动生理学
背景情况:
- 在非肝硬化慢性乙型肝炎 (CHB) 患者中,亚最大有氧能力未得到充分研究.
- 有限的研究存在于CHB患者的身体健康.
研究的目的:
- 为了评估CHB患者的亚最大有氧能力.
- 为了比较CHB患者的身体健康状况与健康的对照组 (CG).
主要方法:
- 进行了6分钟的步行测试 (6MWT).
- 测量包括6分钟步行距离 (6MWD),心率 (HR),氧血红蛋白和 (SpO2),血压和呼吸障碍.
- 计算的6分钟步行工作 (6MWW) 和估计的心肺和肌肉链年龄.
主要成果:
- 与CG相比,CHB患者的6MWD (8%) 和6MWW (10%) 显著降低.
- 冠状动脉瘤患者表现出较高的慢性质缺陷率 (23.08%vs3.57%) 和异常6MWD (34.61%vs3.57%).
- 据估计,CHB使心肺和肌肉链衰老加速了大约11年.
结论:
- 非肝硬化性CHB与下最大有氧能力的降低有关.
- CHB可能会加速心脏呼吸系统和肌肉系统的衰老.
更多相关视频
相关概念视频
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
Bioavailability Study Design: Healthy Subjects Versus Patients
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
Hepatitis
Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction
Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...


