相关实验视频

Updated: May 10, 2025

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Published on: June 14, 2021

内阿弗利伯塞普与或没有肺部位移,用于与多性冠状血管病相关的亚黄斑出血

Taku Wakabayashi¹, Chikako Hara¹, Akihiko Shiraki¹

¹Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan.

Journal of vitreoretinal diseases

|April 28, 2025

概括

肺部位移结合静脉内膜阿弗利塞普与阿弗利塞普单独治疗相比,在患有多重性冠状腺血管病变和亚黄斑出血的患者中显著改善视力敏度. 这种组合疗法为这种情况提供了更好的结果.

科学领域:

眼科医生眼科眼科
视网膜疾病视网膜疾病
血管生物学血管生物学

背景情况:

聚冠状血管病变 (PCV) 是湿时与年龄相关的黄斑变性的一种常见原因.
在PCV中,黄斑下出血 (SMH) 可能导致显著的视力丧失.
内抗血管内皮生长因子 (anti-VEGF) 药物是PCV的标准治疗方法.

研究的目的:

评价吸管内 (IVT) aflibercept与肺部位移治疗的疗效与IVT aflibercept单一治疗与PCV相关的SMH的疗效.
为了比较视觉结果,特别是最佳校正视力敏度 (BCVA),在治疗后12个月.

主要方法:

对47名与PCV相关的SMH患者的回顾性分析.
患者接受了带有肺部位移 (气体) 的IVTaflibercept或IVTaflibercept单一治疗.
主要结局指标是随访12个月后的BCVA.

主要成果:

与单一治疗组相比,aflibercept+gas组在12个月内显示出明显更好的平均BCVA (0.26 ± 0.42) 和BCVA (-0.52 ± 0.55) 的平均变化 (分别为0.85 ± 0.57和0.02 ± 0.75).
在aflibercept+气体组的60.0%的眼睛中,BCVA改善了3条或更多的线,而在单一治疗组中为18.2%.
两组之间在玻璃体出血或视网膜脱落的发生率上没有显著差异.

结论:

与肺部位移结合的静脉内膜阿弗利塞普与阿弗利塞普单独治疗相比,为与PCV相关的SMH提供了更好的视觉结果.
肺部位移是抗VEGF治疗的宝贵补充剂,用于在PCV中管理SMH.
这种方法是改善这种疾病患者视力的有效策略.

关键词:

一个自由的接受.这是一种完全化的.气动移位机的气动移位机多重型冠状血管病变多重型冠状血管病变黄斑下出血黄斑下出血

更多相关视频

An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach

An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach

Published on: December 7, 2016

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology

Published on: May 31, 2024

相关概念视频

Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

Angle Closure Glaucoma: Treatment

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...