循环节障碍改变了小鼠的消费时间,并加剧了小鼠的暴饮暴食
Christopher J Mancuso1, Samantha P Bedard1, Lindsay Gillikin1
1Department of Psychology, University of Wyoming, Laramie, WY, US.
Journal of circadian rhythms
|April 28, 2025
概括
循环节律障碍通过增加高能量饮食的消费,特别是在休息期间,加剧了小鼠的暴饮暴食. 这突出了昼夜节律在饮食行为中的作用,并提出了潜在的治疗目标.
科学领域:
- 神经科学是一个神经科学.
- 时间生物学 时间生物学
- 行为科学 行为科学
背景情况:
- 昼夜节律在调节生理过程中起着至关重要的作用,包括新陈代谢和食欲.
- 昼夜时间的干扰越来越多地与代谢障碍和异常的饮食行为有关,例如过度饮食.
研究的目的:
- 用动物模型调查昼夜干扰在暴饮暴食类饮食行为中的因果作用.
- 为了确定扰乱昼夜系统是否会增加高能量饮食 (HED) 的消费.
主要方法:
- 雄性小鼠接受了基线期的标准食和定期的光暗周期.
- 鼠标经历了狂饮周期,其次是昼夜干扰或正常的光照时间表.
- 测量了食和HED的消费,并使用独立样本t-test分析了群体之间的差异.
主要成果:
- 在昼夜节律受干扰的群体和没有干扰的群体中都观察到过度饮食.
- 与对照小鼠相比,有昼夜干扰的小鼠消耗了明显更多的HED.
- 循环节障碍导致在典型的休息时间 (7:00-19:00) 增加了HED消费.
结论:
- 循环节障碍可能会加剧类似过度饮食的饮食行为,并增加HED消费.
- 改变消费时间,在休息期间增加摄入量,是昼夜干扰的结果.
- 这些发现支持进一步研究导致暴饮暴食的昼夜机制以及潜在的慢性治疗干预措施.
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