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甲状腺激素敏感性受损与糖尿病病在2型糖尿病患者的甲状腺腺患者之间的相关性
Dengrong Ma1, Pingping Zhao1, Jie Gao1
1The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu Province, People's Republic of China.
概括
甲状腺激素敏感性受损与2型糖尿病 (T2DM) 患者的糖尿病病 (DN) 有关. 这种关联与较高的PTFQI和TFQI水平以及较低的FT3/FT4比率观察到,这表明病进展的潜在风险因素.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 代谢疾病 代谢疾病
背景情况:
- 2型糖尿病 (T2DM) 是慢性病的主要原因.
- 糖尿病病 (DN) 是T2DM的主要并发症,显著增加了发病率和死亡率.
- 甲状腺激素在新陈代谢调节中起着至关重要的作用,其敏感性可能会影响糖尿病并发症.
研究的目的:
- 为了研究甲状腺激素敏感性受损和糖尿病病 (DN) 之间的关系,T2DM.
- 探索各种甲状腺激素敏感度指数与DN的存在和严重程度之间的关系.
- 在T2DM患者中确定DN风险评估的潜在生物标志物.
主要方法:
- 分析了1305名患有T2DM的无甲状腺患者队列.
- 用包括 PTFQI,TFQI,TSHI,FT3/FT4比率和TT4RI在内的指数来评估甲状腺激素敏感性.
- 为了确定相关性,使用了统计分析,包括二进制后勤回归和受限立方线 (RCS) 分析.
主要成果:
- 与没有DN的患者相比,DN患者的PTFQI,TFQI和TSHI水平较高,FT3/FT4比率较低.
- 多变量后勤回归证实了增加的PTFQI和TFQI水平与DN之间的正相关性.
- RCS分析显示甲状腺激素敏感度指数和DN之间存在线性剂量反应关系,增加PTFQI,TFQI,TSHI,降低FT3/FT4与更高的DN患病率,升高的UACR和降低的eGFR相关.
结论:
- 甲状腺激素敏感性受损与患有T2DM的乙型甲状腺患者的糖尿病脏病显著相关.
- 尿白蛋白与肌素 (UACR) 的升高和估计球过率 (eGFR) 的降低水平与甲状腺激素敏感性降低有关.
- 这些发现表明,甲状腺激素敏感性可能是DN风险和T2DM进展的潜在指标.
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