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Updated: May 10, 2025

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Published on: February 25, 2022

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在ALS/FTLD中,上下文依赖交互器调节TDP-43功能障碍

Longxin Xie, Yuehua Zhu, Bryan T Hurtle

    bioRxiv : the preprint server for biology
    |April 28, 2025
    PubMed
    概括

    TDP-43蛋白质功能障碍驱动神经退行性疾病,如ALS和FTLD. 这项研究揭示了TDP-43错位化如何破坏拼接,并确定了关键调节者,提供了潜在的治疗点.

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