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Updated: Jul 14, 2026

Lineage-reprogramming of Pericyte-derived Cells of the Adult Human Brain into Induced Neurons
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Lineage-reprogramming of Pericyte-derived Cells of the Adult Human Brain into Induced Neurons

Published on: May 12, 2014

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人类多能干细胞衍生脑细胞的分子特征和功能性质

Ruslan Rust, Abhay P Sagare, Kassandra Kisler

    bioRxiv : the preprint server for biology
    |April 28, 2025
    PubMed
    概括

    人类诱导的多能干细胞衍生细胞体 (iPSC-PC) 密切模仿初级大脑细胞体. 这些iPSC-PC通过修复血脑屏障和清除毒素来显示神经系统疾病中细胞治疗的潜力.

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    Differentiation of Human Induced Pluripotent Stem Cells to Brain Microvascular Endothelial Cell-Like Cells with a Mature Immune Phenotype09:03

    Differentiation of Human Induced Pluripotent Stem Cells to Brain Microvascular Endothelial Cell-Like Cells with a Mature Immune Phenotype

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    Glial Cells01:04

    Glial Cells

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    Source And Potency Of Stem Cells

    Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
    Cell Diversity01:13

    Cell Diversity

    The concept of a cell started with microscopic observations of dead cork tissue by Robert Hooke in 1665. Hooke coined the term "cell" based on the resemblance of the small subdivisions in the cork to the rooms that monks inhabited, called cells. About ten years later, Antonie van Leeuwenhoek became the first person to observe the living and moving cells under a microscope. In the century that followed, the theory that cells represented the basic unit of life developed.
    Multicellular organisms...
    Cellular Differentiation00:57

    Cellular Differentiation

    How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
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