相关实验视频

Updated: May 10, 2025

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
07:20

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

Published on: January 31, 2025

356

在MASH中调节肝脂蛋白分泌和自中,VMP1和TMEM41B在调节肝脂蛋白分泌和自方面具有明显但重叠的功能

Allen Chen, Khue Nguyen, Xiaoxiao Jiang

    bioRxiv : the preprint server for biology
    |April 28, 2025
    PubMed
    概括

    肝脏TMEM41B或VMP1的损失会损害VLDL分泌和自,导致代谢相关的脂肪肝炎 (MASH). TMEM41B和VMP1在肝脏健康方面具有重叠的作用.

    更多相关视频

    Using Scaffold Liposomes to Reconstitute Lipid-proximal Protein-protein Interactions In Vitro08:53

    Using Scaffold Liposomes to Reconstitute Lipid-proximal Protein-protein Interactions In Vitro

    Published on: January 11, 2017

    8.8K
    Reconstitution of Msp1 Extraction Activity with Fully Purified Components05:52

    Reconstitution of Msp1 Extraction Activity with Fully Purified Components

    Published on: August 10, 2021

    2.3K

    相关概念视频

    Intralumenal Vesicles and Multivesicular Bodies01:38

    Intralumenal Vesicles and Multivesicular Bodies

    Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
    3.3K
    Autophagy01:27

    Autophagy

    Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
    An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
    4.0K
    Receptor Downregulation in MVBs01:15

    Receptor Downregulation in MVBs

    Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
    The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR...
    2.0K
    Delivery Pathways to the Lysosome01:36

    Delivery Pathways to the Lysosome

    Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
    Endocytosis
    In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
    6.1K
    Lipid Absorption01:24

    Lipid Absorption

    Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
    These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
    304
    Export of Misfolded Proteins out of the ER01:32

    Export of Misfolded Proteins out of the ER

    After folding, the ER assesses the quality of secretory and membrane proteins. The correctly folded proteins are cleared by the calnexin cycle for transport to their final destination, while misfolded proteins are held back in the ER lumen. The ER chaperones attempt to unfold and refold the misfolded proteins but sometimes fail to achieve the correct native conformation. Such terminally misfolded proteins are then exported to the cytosol by ER-associated degradation or ERAD pathway for...
    3.3K