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Updated: May 10, 2025

In Vivo Modeling of the Morbid Human Genome using Danio rerio
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In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

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一个基因型-表型转换器来评估和解释多基因风险

Ingoo Lee, Zachary S Wallace, Yuqi Wang

    bioRxiv : the preprint server for biology
    |April 28, 2025
    PubMed
    概括

    我们开发了一种新的AI模型,即基因型到表型转换器 (G2PT),以了解遗传变异如何影响健康特征. G2PT通过分析复杂的遗传相互作用,准确地预测代谢健康.

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    Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information09:37

    Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

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    An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations10:17

    An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

    Published on: November 3, 2010

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    Human Genetics01:28

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    The complex relationship between genetics and psychology is observable through common biological components such...
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    Pleiotropy01:33

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    Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
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    Inheritance01:25

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    Gregor Mendel's pioneering work on the principles of inheritance fundamentally transformed our understanding of how traits are transmitted from generation to generation. His experiments with pea plants laid the groundwork for the discovery of genes, discrete units within organisms that control heredity.
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    Epistasis Analysis01:09

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    Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
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