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p-Cymene 抑制亲纤维和炎症媒介,以防止肝功能障碍
Muhammad Atif1, Muhammad Nasir Hayat Malik1, Tariq G Alsahli2
1Faculty of Pharmacy, The University of Lahore, Lahore 54000, Pakistan.
基 (p-CYM) 显示出对酒精诱导的肝损伤和纤维化有显著的肝保护作用. 这种天然化合物提供抗氧化,抗炎和抗纤维性益处,保护肝细胞并改善关键生物标志物.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
背景情况:
- 肝损伤,包括肝细胞损伤和纤维化,对健康构成重大挑战.
- 乙醇 (EtOH) 和二甲基胺碳四化物 (DEN-CCl) 是研究中诱导肝损伤的常见模型.
- 识别具有肝脏保护性质的新型治疗剂至关重要.
研究的目的:
- 在肝损伤实验模型中评估p-cymene (p-CYM) 的肝保护潜力.
- 研究p-CYM对乙醇诱导的肝细胞损伤和DEN-CCl诱导的肝纤维化的影响.
- 阐明p-CYM保护作用的潜在机制.
主要方法:
- 在HepG2细胞中使用乙醇 (EtOH) 诱导肝细胞损伤.
- 在Sprague-Dawley大鼠中,使用二甲基胺 (DEN) 和四化碳 (CCl) 诱导肝纤维化 (LF).
- 动物被用p-cymene (p-CYM) 或silymarin (SIL) 治疗,并进行分子对接.
主要成果:
- 通过增强抗氧化酶活性,p-CYM减轻了HepG2细胞中EtOH诱导的细胞死亡.
- 在体内,p-CYM减弱了DEN-CCl4诱导的肝损伤,改善了血清生物标志物,并减少了纤维变化.
- 基 (p-CYM) 降低了亲炎性和亲纤维性标记物表达,得到了分子对接研究的支持.
结论:
- 基 (p-CYM) 对肝细胞损伤和肝纤维化都有显著的肝保护作用.
- 保护机制包括抗氧化,抗炎和抗纤维活性.
- 基 (p-CYM) 是治疗肝病的有前途的候选药物.
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