在宫癌中,MTHFR多态与PAX1甲基化的相互作用
Xiao-Yan Zhou1, Meng-Meng Chen2, Jun-Mei Yu2
1Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266101, P.R. China.
Open life sciences
|April 28, 2025
概括
高风险的人类乳头瘤病毒 (HR-HPV) 感染,MTHFR基因多态化和PAX1甲基化与子宫病变和癌症有关. PAX1甲基化和MTHFR多态性相互作用增加风险.
科学领域:
- 妇科 妇科 妇科 妇科
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 宫内皮质瘤 (CIN) 和宫癌是严重的健康问题.
- 高风险的人类乳头瘤病毒 (HR-HPV) 感染,甲基四胺叶酸减少酶 (MTHFR) 多态化和配对盒子基因1 (PAX1) 甲基化在子宫癌发生中的作用需要进一步调查.
研究的目的:
- 研究HR-HPV感染,MTHFR多态和PAX1甲基化在CIN和宫癌发展中的个体和相互作用影响.
- 分析这些因素与宫病变的进展之间的相关性.
主要方法:
- 聚合酶链反应 (PCR) 用于检测MTHFR多态和PAX1甲基化.
- 使用Mantle-Haenszel和Spearman的等级相关性测试进行趋势和相关性分析.
- 该研究包括40例正常对照,CIN I,CIN II/III和9例状细胞癌 (SCC) 病例.
主要成果:
- 与正常对照组相比,CIN和SCC组的HR-HPV感染,MTHFR突变和PAX1甲基化率显著增加 (P <0.05).
- 这些比率显示,随着宫病变的严重程度而逐渐增加.
- 在宫病变进展中,PAX1甲基化和MTHFR多态性之间确定了积极的添加相互作用.
结论:
- HR-HPV感染,MTHFR多态和PAX1甲基化是CIN和宫癌的独立危险因素.
- PAX1甲基化和MTHFR多态性表现出一种附加性相互作用,表明对子宫癌发生的联合作用.
- 在宫病变进展中,HR-HPV感染和PAX1甲基化之间没有观察到显著的相互作用.
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