基于临床病理学特征,生活方式和并发症风险因素的确立名录在治愈性内镜子膜下切割中发生超慢性复发的风险因素
Ying Xiang1, Zhenyu Wang2, Yichun Ma1
1Nanjing Drum Tower Hospital, Clinical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
Therapeutic advances in gastroenterology
|April 28, 2025
概括
吸烟,MASLD,脑血管疾病,多发性病变,H. pylori感染和缩性胃炎是EGC治疗后甲基慢性胃癌的关键危险因素. 改变生活方式和定期查可以帮助减轻这些风险.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 超慢性胃癌 (MGC) 在早期胃癌 (EGC) 的内镜切除后越来越令人担忧.
- 胃的保存需要有效的术后监测策略.
- 了解风险因素对于个性化患者管理至关重要.
研究的目的:
- 确定MGC发展后内镜下粘膜切割 (ESD) 的独立风险因素.
- 开发一个MGC风险评估的预测模型.
主要方法:
- 从2014年1月到2020年6月进行的回顾性病例控制研究.
- 分析了南京大学医学院附属鼓楼医院的患者数据.
- 统计分析以确定已识别的风险因素的危险比率和置信区间.
主要成果:
- 确定的MGC风险因素包括吸烟史,代谢功能障碍相关的脂肪性肝病 (MASLD),脑血管疾病 (CD),多种病变,H. pylori感染状态和缩性胃炎 (AG).
- 纳入这些因素的名图显示出高的预测准确性 (一致性指数从0.762到0.845不等).
- 持续的H. pylori感染和严重的缩性胃炎显示出特别高的危险比率.
结论:
- 吸烟,MASLD,CD,多种病变,H. pylori感染和AG是EGC治疗ESD后MGC的重要风险因素.
- 一个名图可以准确地预测MGC风险.
- 建议包括采用健康的生活方式,定期进行H. pylori测试,并每年进行内镜查,以减少MGC风险.
相关概念视频
01:25Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
01:22Photoreceptors and Visual Pathways
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
01:22Microbiome of the Eye
The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
01:27Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...