在糖尿病前期患者中,肝硬度和血清胆素3水平显著增加:一项纤维扫描研究
Huseyin Ali Ozturk1, Hilmi Erdem Sumbul1
1Internal Medicine, Department of Internal Medicine, University of Health Sciences-Adana Health Practice and Research Center, Adana, Turkey.
PeerJ
|April 28, 2025
概括
糖尿病前期患者表现出较高的肝硬度 (LS) 和加勒-3水平,这表明代谢功能障碍相关的脂肪性肝病 (MASLD) 风险增加. 建议对这种人群进行早期的LS和galectin-3评估.
科学领域:
- 内分泌学 在内分泌学.
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
背景情况:
- 糖尿病 (DM) 与代谢功能障碍相关的脂肪性肝病 (MASLD) 的进展有关.
- 糖尿病前期代表了一个中间阶段,有可能发展肝病.
研究的目的:
- 研究糖尿病前期患者的肝硬度 (LS) 和加勒-3水平之间的关联.
- 评估2型糖尿病和正常葡萄糖代谢相比,糖尿病前期患者肝脏健康的标志物.
主要方法:
- 120名参与者 (40名糖尿病前期患者,40名2型糖尿病患者,40名正常葡萄糖代谢患者) 的前性和横截面研究.
- 通过酶链接免疫吸收试验 (ELISA) 测量的加勒-3水平.
- 使用FibroScan® Mini 430设备评估的肝硬度 (LS).
主要成果:
- 糖尿病前期的患者表现出高Fib-4指数,LS和加勒-3水平.
- 在LS≥8kPa的患者中观察到更高的血红蛋白A1c (HbA1c) 和加勒-3水平.
- 无论是HbA1c还是galectin-3,都与LS独立相关.
结论:
- 在糖尿病前期增加的MASLD患病率需要引起注意.
- 建议在糖尿病前期患者中早期评估LS和加勒-3水平,以进行风险分层.
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