胸椎巨细胞瘤:脊髓压缩的一个不寻常的原因

Ghassen Gader1, Fatma Ben Attig1, Wiem Mansour2

  • 1Department of Neurosurgery, Trauma and Burns Center, Ben Arous. University of Tunis - El Manar, Faculty of Medicine of Tunis, Tunisia.

Radiology case reports
|April 28, 2025
PubMed

骨巨细胞瘤(GCT)是一种少见的骨肿瘤,通常发生于长骨的干骺端,脊柱受累较为罕见,尤其是胸椎区域。本文报道一例34岁女性患者,既往有银屑病和乳糜泻病史,因进行性炎性背痛及轻瘫就诊。影像学检查显示T11椎体存在溶骨性肿块,导致胸段脊髓背侧受压。患者接受急诊手术,术后组织病理学检查确诊为骨巨细胞瘤。尽管术后运动功能初期恢复良好,但后期仍需手术固定以预防脊柱不稳。术后开始辅助使用地诺单抗(Denosumab)治疗,随访期间患者无症状。本病例凸显了胸椎骨巨细胞瘤的罕见性及其在诊断与治疗上的挑战。尽管该肿瘤为良性,但仍可引起严重的脊髓压迫,需及时手术干预以保护神经功能。地诺单抗治疗在控制肿瘤进展和改善手术预后方面显示出良好前景。多学科协作管理和定期随访对于预防复发、改善预后至关重要。 关键词:骨巨细胞瘤,脊柱肿瘤,胸椎,脊髓压迫,地诺单抗,手术治疗,多学科管理,随访

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