Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Other Pulmonary Disorders01:17

Other Pulmonary Disorders

1.8K
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
1.8K
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

159
Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
159
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

81
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
81
Human Genetics01:28

Human Genetics

2.0K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
2.0K
Sleep Apnea01:21

Sleep Apnea

914
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
914
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

21
Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
21

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Insomnia and the question of psychomotor agitation as a possible cause for zolpidem abuse.

Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia·2026
Same author

Frailty and Recurrent Cardiovascular Events in Patients With Obstructive Sleep Apnoea: The SAVE Study.

Journal of cachexia, sarcopenia and muscle·2026
Same author

Obstructive sleep apnea in adults with Down syndrome: body composition, metabolic profile and cognitive status.

Clinics (Sao Paulo, Brazil)·2026
Same author

The impact of exercise training on the obstructive sleep apnea endotypes.

Sleep medicine·2025
Same author

Feasibility of neck electrical impedance tomography to monitor upper airway dynamics during sleep.

Frontiers in sleep·2025
Same author

Impact of oximetry resolution on detection of oxyhemoglobin desaturation events and hypoxic burden in patients with obstructive sleep apnea.

Sleep medicine·2025

相关实验视频

Updated: May 5, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

19.8K

多形态,阻塞性睡眠呼吸暂停和认知功能.

Elisangela Macedo Gara1, Thiago Tanaka Goya2, Rosyvaldo Ferreira-Silva1

  • 1Escola de Artes, Ciências e Humanidades, Universidade de São Paulo, São Paulo, SP, Brazil.

Sleep science (Sao Paulo, Brazil)
|April 28, 2025
PubMed
概括

中度至重度的阻塞性睡眠呼吸暂停 (OSA) 会损害认知功能,特别是处理速度和注意力. 阿波利波蛋白E ε4 (APOE ε4) 基因基因进一步恶化了OSA患者的情节性记忆.

关键词:
这是一种Apolipoprotein蛋白.认知 认知 认知睡眠 睡眠 睡眠 睡眠 睡眠

更多相关视频

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

5.3K
Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach
04:53

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

Published on: October 18, 2024

1.6K

相关实验视频

Last Updated: May 5, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

19.8K
A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

5.3K
Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach
04:53

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

Published on: October 18, 2024

1.6K

科学领域:

  • 神经科学是一个神经科学.
  • 遗传学 是一个遗传学.
  • 睡眠医学 睡眠医学

背景情况:

  • 阻塞性睡眠呼吸暂停 (OSA) 与认知缺陷和阿波利波蛋白E ε4 (APOE ε4) 等位基因有关.
  • APOE ε4对中度至重度OSA认知功能的特定影响仍在争论中.
  • 这项研究侧重于没有重大并发症的久坐性OSA患者.

研究的目的:

  • 研究APOE ε4多态对中度至重度OSA患者认知功能的影响.
  • 评估与OSA严重程度和APOE ε4状态相关的认知表现.

主要方法:

  • 55名中年患者接受了多睡眠扫描,APOE ε4基因定型和认知评估 (注意力,记忆力,处理速度).
  • 国际体育活动问卷被用来评估体育活动水平.
  • 患者被分为轻度OSA (n=13) 和中度至重度OSA (n=42) 组.

主要成果:

  • 与轻度OSA患者相比,中度至重度OSA患者的处理速度和注意力较差,无论APOE ε4状态如何.
  • 与非载体相比,具有中度至重度OSA的APOE ε4载体表现出较差的情节性记忆.
  • 在中度至重度OSA组中,在APOE ε4载体和非载体之间,睡眠参数是可比的.

结论:

  • 中度至重度的OSA独立地与认知障碍有关.
  • 在OSA患者中,APOE ε4等位基因的存在会加剧认知缺陷,特别是情节性记忆.
  • 这些发现凸显了OSA和APOE ε4对认知的综合负面影响.