相关实验视频

Updated: May 10, 2025

Expanding the Comprehension of the Tumor Microenvironment using Mass Spectrometry Imaging of Formalin-Fixed and Paraffin-Embedded Tissue Samples

Expanding the Comprehension of the Tumor Microenvironment using Mass Spectrometry Imaging of Formalin-Fixed and Paraffin-Embedded Tissue Samples

Published on: June 29, 2022

从冲浪到潜入瘤微环境,通过多参数成像质量细胞计

Marco Erreni^1,2, Maria Rita Fumagalli¹, Matteo Marozzi¹

¹Unit of Multiscale and Nanostructural Imaging, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.

Frontiers in immunology

|April 28, 2025

概括

图像质量细胞计 (IMC) 分析瘤微环境 (TME) 中的细胞相互作用. 这项技术增强了对癌症进展的理解,并有助于识别耐药性生物标志物.

科学领域:

在瘤学瘤学.
生物技术是生物技术.
细胞生物学细胞生物学

背景情况:

瘤微环境 (TME) 是一个复杂的细胞生态系统,对癌症进展至关重要.
了解TME的时空动态对于瘤疾病病因至关重要.
治疗干预显著改变TME组成,表型和细胞局部.

研究的目的:

描述成像质细胞计 (IMC) 的原理和工作流程.
突出IMC在瘤微环境的现场分析方面的潜力.
强调IMC在促进癌症研究中的作用.

主要方法:

使用成像质量细胞计 (IMC) 进行多重成像.
同时分析多达43种蛋白质标记物.
在保存的微环境中对细胞进行现场调查.

主要成果:

IMC允许对细胞进行深入的表型和空间研究.
该技术定义了TME内的细胞景观组成.
IMC 识别了与药物耐药性机制相关的生物标志物.

结论:

IMC是一种用于癌症研究的可选多重成像技术.
IMC增强了癌症临床前和临床研究中的信息潜力.
进一步应用IMC将加深对癌症发展和治疗的洞察力.

关键词:

癌症癌症癌症癌症癌症图像成像质量细胞计量.多重复合组织病理学.胰腺癌是一种癌症.瘤微环境是一个微环境.

更多相关视频

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

Published on: March 25, 2020

Author Spotlight: Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment

Author Spotlight: Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment

Published on: June 2, 2023

相关概念视频

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...