循环节律障碍和多囊性卵巢综合征:一个系统性审查和元分析
相关实验视频
Updated: Jun 15, 2026

08:20
A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
Published on: October 2, 2018
Tara Heydari1, Prakash V A K Ramdass1
1Department of Public Health and Preventive Medicine (Heydari, and Ramdass), School of Medicine, St. George's University, St. George's, Grenada.
AJOG global reports
|April 28, 2025
概括
循环节律障碍 (CRD) 与多囊性卵巢综合征 (PCOS) 有关. 这项系统性审查发现,PCOS女性的黑激素水平较高,晚间皮质醇水平改变,睡眠效率较低,表明昼夜节律受损.
科学领域:
- 内分泌学 在内分泌学.
- 睡眠医学 睡眠医学
- 生殖健康 生殖健康
背景情况:
- 多囊卵巢综合征 (PCOS) 是一种常见的内分泌疾病.
- 循环节律扰乱 (CRD) 影响了许多生理过程.
- 需要进一步调查CRD和PCOS之间的关系.
研究的目的:
- 系统地审查和元分析CRD和PCOS之间的关联.
- 在PCOS患者和对照者之间比较CRD的生物标志物,包括黑激素,皮质醇和睡眠效率.
主要方法:
- 在主要数据库 (PubMed,Scopus,Embase等) 中进行系统搜索. 在2024年之前.
- 包括对患有PCOS和CRD参数的妇女的病例控制,横截面和队列研究.
- 使用纽卡斯尔-太华尺度进行质量评估,使用Open Meta Analyst软件进行元分析.
主要成果:
- 包括16项研究 (1,100名女性);12项在元分析中.
- 在PCOS患者中,黑激素水平显著上升 (平均差异为14.294 pg/mL).
- 与对照组相比,PCOS患者的晚间皮质醇增加 (3.574 pg/mL) 和睡眠效率降低 (-4.059).
结论:
- 循环节律障碍与多囊性卵巢综合征有积极的关联.
- 黑色素,晚间皮质醇和睡眠效率的差异支持了这一关联.
- 这些发现强调了昼夜健康在PCOS管理中的重要性.
相关概念视频
Oogenesis
63.1K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.1K
Circadian Rhythms and Gene Regulation
4.0K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.0K
Hormonal Regulation of the Menstrual Cycle
183
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
183
Ovarian Cycle
692
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
692
Hormonal Control of the Ovarian Cycle
311
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
311
Disorders of the Female Reproductive System
204
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
204

