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反应参数对基于循环二烯的纳米结构聚合物的合成对药物输送的反应参数的影响

Sema Salgın¹, Hasan Hüseyin Eke², Nagihan Soyer¹

¹Department of Chemical Engineering, Faculty of Engineering, Sivas Cumhuriyet University, 58140 Sivas, Turkey.

|April 28, 2025

概括

这项研究合成了基于环氧的纳米结构 (CDNS) 用于药物输送. 在优化条件下,阿尔法-CDNS与β-CDNS相比,显示出更高的纳普罗森加载效率.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
制药科学制药科学

背景情况:

基于循环烯的纳米结构 (CDNS) 为药物输送应用提供了潜力.
纳普 (NAP) 是一种非类固醇抗炎药物,其水溶性较差,需要改进的输送系统.

研究的目的:

为了合成和描述基于α-cyclodextrin的纳米结构 (α-CDNS) 和基于β-cyclodextrin的纳米结构 (β-CDNS).
研究反应参数对CDNS的物理化学性质和药物载荷能力的影响.
为了评估合成的CDNSs的药物加载效率,使用纳普 (NAP) 作为模型药物.

主要方法:

通过循环德克斯特林 (CDs) 与水素 (ECH) 的交叉链接合成了CDNS.
反应参数包括溶解时间,ECH/CD 摩尔比率和NaOH度系统地变化.
使用NAP评估药物载荷能力,并使用FTIR,DSC,XRD,SEM和Zetasizer分析进行表征;药物度通过HPLC量化.

主要成果:

对CDNS的最佳合成条件被确定为6小时的溶解时间,8/1的ECH/CD摩尔比率和33%的NaOH度.
在最佳条件下,α-CDNS可以达到67.12%的纳普洛克森加载效率.
对比分析表明,α-CDNS表现出比β-CDNS更高的药物载荷能力.

结论:

基于环德的优化纳米结构,特别是α-CDNSs,显示出增强纳素等水溶性较差药物的负载的巨大潜力.
该研究提供了通过反应参数优化来控制CDNS属性的见解,以改善药物输送系统.

关键词:

循环德克斯林 (Cyclodextrin) 是一种循环德克斯林.毒品运输商毒品运输商化水氨酸 (Epichlorohydrin) 是一种化水氨酸.纳米结构是一种纳米结构.

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