多糖的结构性表征 Dendrobium officinale 多糖和它们在体外发酵过程中对肠道微生物群的调节效应
Yanlei Yu1, Honggang Wang1, Xiaoshu Jin1
1College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.
Polymers
|April 28, 2025
概括
来自不同地区的Dendrobium officinale多糖 (DOP) 具有独特的结构,通过调节肠道微生物群组成来调节新陈代谢,促进有益细菌和抑制病原体.
科学领域:
- * 植物化学和营养药品
- *肠道微生物组研究
- * 代谢调节 代谢调节 代谢调节
背景情况:
- * Dendrobium officinale 多糖 (DOP) 显示了代谢调节的潜力.
- * DOP 的结构功能关系和肠道微生物群机制尚不清楚.
研究的目的:
- * 描述来自贵州 (GZ) 和江 (ZJ) 省的标称产品的结构特征.
- *通过α-葡萄糖酶抑制和肠道微生物群调节来研究DOP的代谢调节活动.
- *通过肠道微生物群相互作用探索DOP代谢调节的机制.
主要方法:
- *使用核磁共振 (NMR) 和色谱技术进行结构分析.
- *对α-葡萄糖酶抑制活性进行体外评估.
- * 在体外评估肠道微生物群的组成和活性.
主要成果:
- *DOP-GZ和DOP-ZJ具有不同的单糖比 (2.51:1和2.66:1曼:葡萄糖) 和分子量 (356kDa和544kDa).
- * 两种DOP都显著改变了肠道微生物群α-多样性和Firmicutes-to-Bacteroidota比率.
- *DOP促进了有益细菌 (例如,g_Proteobacteria_未分类) 和抑制了致病细菌 (例如,f_Enterobacteriaceae_未分类).
结论:
- *DOP的独特结构特征与它们的代谢调节功能相关.
- *DOP通过有益调节肠道微生物群来调节新陈代谢.
- *这些发现为功能性食品和药品中的DOP提供了基础.
相关概念视频
Structuralism
495
Structuralism, an early psychological theory developed by Wilhelm Wundt and his student Edward Bradford Titchener, sought to dissect the human mind into its most fundamental components. Wundt's groundbreaking work in his laboratory set the stage for Titchener to define structuralism's goal as cataloging the "atoms" of the mind—sensations, images, and feelings—akin to how chemists identify elements of matter.
Titchener's approach to structuralism was unique. He...
Titchener's approach to structuralism was unique. He...
495
Introduction to Structures
925
A structure is defined as a system of interconnected members designed to support or transfer forces and successfully withstand the loads acting on them. The internal forces of a structure can be determined by decomposing the structure and analyzing the free-body diagrams of the individual members or of a combination of members. This helps in understanding the structural elements' behavior and ensuring that the structure is stable and can withstand the subjected loads.
There are three main...
There are three main...
925
Resonance and Hybrid Structures
16.1K
According to the theory of resonance, if two or more Lewis structures with the same arrangement of atoms can be written for a molecule, ion, or radical, the actual distribution of electrons is an average of that shown by the various Lewis structures.
Resonance Structures and Resonance Hybrids
The Lewis structure of a nitrite anion (NO2−) may actually be drawn in two different ways, distinguished by the locations of the N–O and N=O bonds.
Resonance Structures and Resonance Hybrids
The Lewis structure of a nitrite anion (NO2−) may actually be drawn in two different ways, distinguished by the locations of the N–O and N=O bonds.
16.1K
Polymer Classification: Architecture
2.6K
Polymers are classified as linear or branched on the basis of their chain architecture. The polymer chains in linear polymers have a long chain-like structure with minimal to no branching at all. Even if a polymer features large substituent groups on the monomer, which appear as branches to the skeleton, it is not considered a branched polymer. A branched polymer contains secondary polymer chains that arise from the main polymer chain. The branching occurs when the polymer growth shifts from...
2.6K
Polymer Classification: Stereospecificity
2.3K
Polymerization generates chiral centers along the entire backbone of a polymer chain. Accordingly, the stereochemistry of the substituent group has a significant effect on polymer properties. Polymers formed from monosubstituted alkene monomers feature chiral carbons at every alternate position in the polymer backbone. Relative to the predominant orientation of substituents at the adjacent chiral carbons, the polymer can exist in three different configurations: isotactic, syndiotactic, and...
2.3K
Qualitative Analysis
185
Qualitative analysis is the process of identifying elements, ions, or compounds in an unknown sample. It is the first and most fundamental type of analysis based on the hierarchy of analytical goals. This hierarchy is significant as it provides a structured approach to scientific research, with qualitative analysis serving as the initial step, providing essential information before moving on to quantitative or other forms of analysis.
There are two main approaches to qualitative analysis:...
There are two main approaches to qualitative analysis:...
185


