灰色物质共变网络与父母的长寿有关 - - 来自LonGenity研究的结果
Natalie Delpratt1, Nir Barzilai1,2, Sofiya Milman1,2
1Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
概括
长寿父母的后代表现出明显的脑灰质模式,与衰老中的更好的认知功能有关. 这个大脑网络与整体认知和特定的认知测试有关.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 老年学是一门学科.
背景情况:
- 父母的异常长寿与后代的健康和疾病保护有关.
- 以前的研究表明,长寿父母的后代具有更大的特定脑区.
- 父母长寿与老年人大脑结构之间的关系需要进一步研究.
研究的目的:
- 在老年人中识别与父母长寿相关的灰质体积模式.
- 为了确定这种灰色物质模式是否与老年人的认知表现相关.
主要方法:
- 利用了来自LonGenity研究的139名老年人的数据.
- 异常长寿的父母的后代与通常的生存率相比较.
- 采用基于多变量共变的分析来得出灰色物质网络,并根据认知测试结果进行回归.
主要成果:
- 一个灰色物质共变网络,包括额头,岛屿和海马区域,与父母的长寿有关.
- 老年人表现出这种网络的程度与整体认知能力相关.
- 特定的认知功能,包括记忆,处理速度和执行功能,与这种大脑模式有关.
结论:
- 父母的长寿与老年人大脑区域分布的网络有关.
- 这种确定的大脑网络的变化与认知表现相关,这表明遗传学,大脑结构和认知衰老之间存在联系.
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