相关实验视频
Updated: May 10, 2025

05:11
Inkjet-printed Polyvinyl Alcohol Multilayers
Published on: May 11, 2017
12.5K
在PVP和PVPVA中对过氧化的量化使用H qNMR光谱学
Isha Saraf1, Varun Kushwah1, Bernd Werner2
1Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, 8010 Graz, Austria.
Polymers
|April 28, 2025
概括
定量质子核磁共振 (1H qNMR) 光谱学准确地测量了PVP和PVPVA等制药辅助剂中的过氧化物水平. 这通过控制氧化降解来确保药物产品的安全性和有效性.
科学领域:
- 制药科学 制药科学
- 分析化学 分析化学
- 频谱学是一种光谱学.
背景情况:
- 制药辅助剂中的过氧化物可以氧化药物,导致毒性和有效性降低.
- 精确的过氧化物量化对于确保药品安全性和功效至关重要.
研究的目的:
- 评估量子质子核磁共振 (1H qNMR) 光谱法用于药品辅助剂中敏感和特定的过氧化物量化.
- 评估聚乙烯酸 (PVP) 和聚乙烯酸/乙烯酸乙烯酸 (PVPVA) 助剂中的过氧化物含量.
主要方法:
- 1H qNMR光谱法被用于量化过氧化物水平到0.1 ppm.
- 分析的重点是PVP和PVPVA的各种等级和供应商.
- 研究了制造工艺对过氧化含量的影响.
主要成果:
- 过氧化物水平在PVP和PVPVA的不同等级和供应商之间表现出显著的差异.
- 发现制造工艺会影响分析助剂中的过氧化含量.
- 这些发现强调了控制原材料和生产过程中的过氧化物水平的必要性.
结论:
- 1H qNMR光谱学提供了一种有价值和准确的方法来量化制药辅助剂中的过氧化物水平.
- 定期监测过氧化物含量对于保持辅助剂和最终药物产品的稳定性,质量和安全性至关重要.
- 精确的过氧化物测量是防止氧化降解和保持药物安全性和有效性的关键.
相关概念视频
Vapor Pressure Lowering
25.3K
The equilibrium vapor pressure of a liquid is the pressure exerted by its gaseous phase when vaporization and condensation are occurring at equal rates:
Dissolving a nonvolatile substance in volatile liquid results in a lowering of the liquid’s vapor pressure. This phenomenon can be explained by considering the effect of added solute molecules on the liquid's vaporization and condensation processes. To vaporize, solvent molecules must be present at the surface of the solution....
Dissolving a nonvolatile substance in volatile liquid results in a lowering of the liquid’s vapor pressure. This phenomenon can be explained by considering the effect of added solute molecules on the liquid's vaporization and condensation processes. To vaporize, solvent molecules must be present at the surface of the solution....
25.3K
Strong Acid and Base Solutions
30.8K
A strong acid is a compound that dissociates completely in an aqueous solution and produces a concentration of hydronium ions equal to the initial concentration of acid. For example, 0.20 M hydrobromic acid will dissociate completely in water and produces 0.20 M of hydronium ions and 0.20 M of bromide ions.
30.8K
Titration Calculations: Weak Acid - Strong Base
43.5K
Calculating pH for Titration Solutions: Weak Acid/Strong Base
For the titration of 25.00 mL of 0.100 M CH3CO2H with 0.100 M NaOH, the reaction can be represented as:
For the titration of 25.00 mL of 0.100 M CH3CO2H with 0.100 M NaOH, the reaction can be represented as:
43.5K
Polyprotic Acids
28.5K
Acids are classified by the number of protons per molecule that they can give up in a reaction. Acids such as HCl, HNO3, and HCN that contain one ionizable hydrogen atom in each molecule are called monoprotic acids. Their reactions with water are:
28.5K
Autoxidation of Ethers to Peroxides and Hydroperoxides
7.2K
Ethers represent a class of chemical compounds that become more dangerous with prolonged storage because they tend to form explosive peroxides when standing in the air. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly oxidize to form hydroperoxides and dialkyl peroxides.
7.2K
Composition of Polyprotic Acid Solutions as a Function of pH
467
Polyprotic acids of the type H2M constitute two ionizable protons. As a result, on titration with a base, they exhibit two equivalence points in the titration curve. During titration, the species H2M, HM−, and M2− will be present in the solution at different points. The fractions of H2M, HM−, and M2− present at the various instances of the titration are denoted by α0, α1, and α2, respectively.
A graph with the alpha values is plotted against the volume of...
A graph with the alpha values is plotted against the volume of...
467

