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用于牙科应用的植物性化合物的粘膜聚合物薄膜:配方,表征和评估

Yuliia Maslii¹, Nataliia Herbina¹, Lina Dene^2,3

¹Department of Drug Technology and Social Pharmacy, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Pharmaceutical development and technology

|April 28, 2025

概括

粘膜牙膜含有丁香,衣草和葡萄油,为口腔疾病提供持续的药物输送. 优化的配方表现出强大的粘附性和抗菌性质,用于增强局部治疗.

科学领域:

制药科学制药科学
材料科学材料科学材料科学
生物技术是生物技术.

背景情况:

聚合物薄膜对于口腔粘膜药物输送是有效的,特别是在局部牙科治疗中.
牙科疾病需要局部治疗,具有长时间的治疗效果.

研究的目的:

开发和优化用于牙科应用的粘膜,使用天然活性成分.
评估开发的薄膜的物理化学,粘粘性和药物释放性质.

主要方法:

溶剂造方法用于用各种薄膜成形剂和可塑剂制备薄膜.
综合评估薄膜特性,包括外观,厚度,pH值,湿度,机械强度,溶解和粘附.
在体外对广泛的微生物进行抗菌活性测试.

主要成果:

最优的薄膜配方结合了基乙烯纤维素,基基纤维素和聚乙烯糖醇 400.
片表现出优异的感官,物理化学和纹理特征,具有强大的粘膜粘合力 (9.20 ± 0.58 N).
持续释放的欧原醇 (大约. 通过420分钟) 和显著的抗菌活性被观察到.

结论:

开发的粘膜膜为牙科应用的活性成分的局部和持续输送提供了一个有前途的平台.
这些膜显示出治疗传染性和炎症性口腔疾病的潜力,因为它们的粘膜粘合,持续释放和抗菌性质.

关键词:

粘膜聚合物膜是一种粘膜.的二氧化碳提取物衣草和葡萄的精油和葡萄的精油.评价评价评价评价这是一种配方配方.塑化剂是一种可塑化剂.一个聚合物聚合物.

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