氨酸和紫氨酸用于降低早产婴儿的发病率和死亡率
Yao Mun Choo1, Ke Xin Yip2, Michelle Fiander3
1Department of Paediatrics, University of Malaya, Kuala Lumpur, Malaysia.
The Cochrane database of systematic reviews
|April 28, 2025
概括
在早产婴儿中补充黄素和黄素可能会减少早产严重视网膜病变 (ROP),但对整体ROP,IVH,NEC或死亡率的影响很小. 需要进一步的试验来证实这些发现.
科学领域:
- 新生儿医学 新生儿医学
- 营养科学 营养科学
- 眼科医生 眼科 眼科
背景情况:
- 氨酸和紫氨酸具有对眼睛和大脑健康有益的抗氧化特性.
- 氧自由基涉及到早产婴儿疾病,如ROP,IVH和NEC.
- 补充剂可以减轻氧化损伤,可能减少早产婴儿的发病率和死亡率.
研究的目的:
- 为了评估白蛋白和紫素补充剂在降低早产婴儿的发病率和死亡率方面的疗效.
- 分析对特定新生儿疾病的影响,包括ROP,IVH和NEC.
主要方法:
- 随机对照试验 (RCT) 的系统审查和元分析.
- 在CENTRAL,MEDLINE,Embase和试验注册表中进行的搜索截至2024年12月.
- 包括RCT比较黄蛋白/泽亚桑丁补充剂与安慰剂/没有补充剂在早产婴儿 (<37周的月经后年龄) 中.
主要成果:
- 包括5个RCT (666名婴儿);研究来自高收入国家.
- 补充可能会减少ROP阶段3及以上 (中等确定性证据).
- 对ROP (任何阶段),死亡率,IVH或NEC (低至中等确定性证据) 观察到几乎没有影响. 没有报告任何不良影响.
结论:
- 氨酸和紫氨酸补充剂可能会减少早产婴儿严重的ROP.
- 证据表明对整体ROP,IVH,NEC和死亡率的影响有限.
- 建议进行进一步的严格试验,以巩固发现并探索潜在的益处.
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