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超越创伤的扩展:在需要大规模输血协议激活的儿童中,描述低标位组O全血 (LTOWB) 的使用情况

Erin V Feeney¹, Elissa Abou Khalil², Barbara A Gaines³

¹Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

|April 28, 2025

概括

低标位组O全血 (LTOWB) 是可行的在重度出血的儿科患者静血复苏. 这项研究发现LTOWB在非创伤儿科病例中使用安全有效,尽管需要进一步研究.

科学领域:

儿科重症监护医药儿科重症监护医药
输血药物输血药物输血药物
流血性休克管理的管理.

背景情况:

有限的数据存在于低标位组O全血 (LTOWB) 在非创伤儿科患者的使用.
现有的证据主要来自成人创伤队伍.

研究的目的:

评估LTOWB在需要大量输血的未受伤儿科患者中使用的可行性和结果.
评估LTOWB在患有不同出血病因的儿科患者群体中的安全性和有效性.

主要方法:

在2016-2023年期间通过大规模输血协议 (MTP) 接受LTOWB的儿科患者 (<18岁) 的回顾性观察研究.
不包括受伤的儿童;数据包括人口统计,出血原因,血量,死亡率,器官功能障碍和血液溶解标记.
组O和组O以外的LTOWB受益人之间的结果比较.

主要成果:

16名儿科患者符合纳入标准;中位数年龄为13岁.
常见的出血病因包括外科手术,胃肠道和ECMO管.
24小时死亡率为25%,住院死亡率为44%;急性损伤 (AKI) 是最常见的并发症 (63%).
在O组和O组以外的LTOWB接受者之间没有观察到血液溶解标记的显著差异.

结论:

在患有各种非创伤性出血疾病的儿科患者中,LTOWB可用于静血复苏.
需要进行更大规模的前性研究,以确定在这个人群中使用LTOWB的最佳指南.

关键词:

发生出血发生出血大规模的输血输血.没有创伤的非创伤.儿科儿科儿科整体血是什么意思?全血是什么意思?

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