放置在母牙上的不钢皇冠对GCF生物化学参数的影响:系统性审查
Mario Alberto Alarcón-Sánchez1, Julieta Sarai Becerra-Ruiz2, Ruth Rodríguez-Montaño3,4
1Biomedical Science, Faculty of Chemical-Biological Sciences, Autonomous University of Guerrero, Chilpancingo de los Bravo, Mexico.
Journal of applied biomaterials & functional materials
|April 28, 2025
概括
初始牙中的不钢皇冠 (SSC) 与牙裂液 (GCF) 中关键炎症标记物的水平增加有关. 这一发现突显了接受SSC恢复的儿童潜在的炎症反应.
科学领域:
- 生物材料和牙科修复
- 免疫学和炎症 免疫学和炎症
- 儿科牙科 儿科牙科
背景情况:
- 牙裂液 (GCF) 含有反映当地的炎症状态的生物标志物.
- 不钢皇冠 (SSC) 通常用于初级牙修复.
- 了解与SSC相关的炎症概况对于儿科牙科护理至关重要.
研究的目的:
- 系统地审查和总结有关GCF中促炎性细胞因子和化学因子的文献.
- 为了比较用SSC恢复的初级牙与对照牙中的GCF炎症标志物水平.
- 调查这些标志物在与SSC相关的牙炎症中的作用.
主要方法:
- 在开放科学框架 (OSF.IO/39U4D) 中注册的系统审查,并遵守PRISMA指南.
- 从1999年到2024年,搜索了五个数据库 (PubMed,Scopus,ScienceDirect,Web of Science,Google Scholar) 在这些数据库中.
- 通过Joanna Briggs Institute和Cochrane RoB 2.0标准评估偏差风险;通过ELISA分析了GCF样本.
主要成果:
- 包括四项研究 (2个横截面,2个RCT) 涉及75名儿童 (3-10岁).
- 在SSC的牙的GCF中发现了高水平的互白素-1β (IL-1β),巨细胞炎症蛋白-1α (MIP-1α) 和MIP-1β (MIP-1β).
- 在SSC和对照组之间观察到IL-1β (p<0.05),MIP-1α (p<0.05) 和MIP-1β (p<0.05) 的显著差异.
结论:
- 在母牙中SSC的修复与IL-1β,MIP-1α和MIP-1β的GCF水平增加有关.
- 这些发现为SSC儿童的牙炎症的病变产生提供了洞察力.
- 进一步的研究可能会探索这些炎症标志物升高的临床影响.
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