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TNFR2/CCR8双特异性抗体通过耗尽Ti-Tregs增强抗瘤活性,并增强效应因子CD8+ T细胞功能

Ran Wang1, Jiefang Xu1, Shipeng Cheng2

  • 1Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

Oncoimmunology
|April 28, 2025
PubMed
概括

一种新的双特异性抗体FT10-Fab精确地准并消耗瘤透调节T细胞 (Ti-Tregs). 这种方法可以增强抗瘤免疫力,并且在结合PD-1阻断用于癌症免疫治疗时显示出有前途.

关键词:
CCR8 CCR8 的意思是什么?在 CD8+ T 细胞中.在FT10-Fab中使用.这就是TNFR2的特点.在Ti-Tregs中.这是一种抗瘤药物.免疫疗法 免疫疗法

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