概括
过度的甲状腺功能低下症 (OH) 与由于大脑网络拓学的改变而导致的情绪和认知缺陷有关. 大脑连接的这些变化可能是OH患者观察到的损伤的基础.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 精神病学是一个精神病学.
背景情况:
- 过度的甲状腺功能低下 (OH) 可以导致显著的情绪和认知障碍.
- 大脑白质网络完整性对于认知和情绪处理至关重要.
研究的目的:
- 在明显的甲状腺功能低下症 (OH) 患者中调查大脑白质网络的拓性质.
- 探索这些拓性质与OH的认知和情绪功能障碍之间的关系.
主要方法:
- 大脑磁共振成像 (MRI) 和扩散张力成像 (DTI) 用于50名OH患者和92名健康对照.
- 图形理论网络分析计算了白质网络的全球和局部拓特性.
- 进行了神经心理评估和临床评估.
主要成果:
- 在OH患者中,抑郁和焦虑得分较高,认知功能较低.
- 在OH患者中观察到大脑网络的整体效率下降,与抑郁症严重程度相关.
- 在边缘系统和默认模式网络中发现了局部拓异常,特别是节点效率,与情绪和认知得分相关.
结论:
- 过度的甲状腺功能低下症与大脑白质网络拓学的显著改变有关.
- 这些拓变化,特别是在边缘系统和默认模式网络中,与OH的情绪和认知障碍有关.
- 这项研究提供了对这些功能障碍的神经病理生理学的基础的见解.
更多相关视频
相关概念视频
Cerebrum: Anatomical Overview II
1.4K
Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...
1.4K
Magnetic Resonance Imaging
4.9K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
4.9K


