肌肉mTOR通过NRF2,HIF和AKT/PKB信号通路控制铁稳态和铁

Agnès Conjard-Duplany1, Alexis Osseni2, Aline Lamboux3

  • 1Laboratoire Physiopathologie et Génétique du Neurone et du Muscle (PGNM), Institut NeuroMyoGène, Université Claude Bernard Lyon 1, INSERM U1315, CNRS UMR 5261, 8 avenue Rockefeller, Lyon, 69008, France. agnes.duplany@univ-lyon1.fr.

概括

哺乳动物目标的拉巴胺素 (mTOR) 缺乏会破坏肌肉的铁代谢,导致铁失调和肌肉病变. 精子胺补充剂可能有助于通过改善ferritinophagy恢复铁平衡和肌肉健康.

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