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相关概念视频

Hydrogen Bonds01:04

Hydrogen Bonds

7.7K
A hydrogen bond is formed when a weakly positive hydrogen atom already bonded to one electronegative atom (for example, the oxygen in the water molecule) is attracted to another electronegative atom from another polar molecule, such as water (H2O), hydrogen fluoride (HF), or ammonia (NH3). The huge electronegativity difference between the H atom (2.1) and the atom to which it is bonded (4.0 for an F atom, 3.5 for an O atom, or 3.0 for an N atom), combined with the very small size of an H atom...
7.7K
IR Spectrum Peak Broadening: Hydrogen Bonding01:23

IR Spectrum Peak Broadening: Hydrogen Bonding

763
The vibrational frequency of a bond is directly proportional to its bond strength. As a result, stronger bonds vibrate at higher frequencies, while weaker bonds vibrate at lower frequencies. The stretching vibration of the strong O–H bond in alcohols and phenols (very dilute solution or gas phase) appears as a sharp peak at 3600–3650 cm−1.
However, the extent of hydrogen bonding influences the observed stretching frequency and band broadening. Intermolecular or intramolecular...
763
Bond Energies and Bond Lengths02:49

Bond Energies and Bond Lengths

24.8K
Stable molecules exist because covalent bonds hold the atoms together. The strength of a covalent bond is measured by the energy required to break it, that is, the energy necessary to separate the bonded atoms. Separating any pair of bonded atoms requires energy — the stronger a bond, the greater the energy required to break it.
24.8K
¹H NMR of Conformationally Flexible Molecules: Variable-Temperature NMR01:15

¹H NMR of Conformationally Flexible Molecules: Variable-Temperature NMR

1.0K
The axial and equatorial protons in cyclohexane can be distinguished by performing a variable-temperature NMR experiment. In this process, except for one proton, the remaining eleven protons are replaced by deuterium. The deuterium substitution avoids the possible peak splitting caused by the spin-spin coupling between the adjacent protons. The remaining proton flips between the axial and equatorial positions.
1.0K
Noncovalent Attractions in Biomolecules02:35

Noncovalent Attractions in Biomolecules

46.0K
Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
46.0K
IR Spectroscopy: Hooke's Law Approximation of Molecular Vibration01:16

IR Spectroscopy: Hooke's Law Approximation of Molecular Vibration

1.1K
A covalently bonded heteronuclear diatomic molecule can be modeled as two vibrating masses connected by a spring. The vibrational frequency of the bond can be expressed using an equation derived from Hooke's law, which describes how the force applied to stretch or compress a spring is proportional to the displacement of the spring. In this case, the atoms behave like masses, and the bond acts like a spring.
According to Hooke's law, the vibrational frequency is directly proportional to...
1.1K

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Determination of Protein-ligand Interactions Using Differential Scanning Fluorimetry
13:26

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Published on: September 13, 2014

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键强度与温度之间的相关性:在广泛的温度范围内进行量化单分子研究.

Minghan Hu1, Jiulong Zhou2, Li Jiang3

  • 1School of Chemistry, Key Laboratory of Advanced Technologies of Materials (Ministry of Education), Southwest Jiaotong University, Chengdu 610031, China.

The journal of physical chemistry. B
|April 28, 2025
PubMed
概括

本研究量化了温度如何影响键 (H键) 强度,使用可变温度单分子力谱学. 结果显示,H键强度随着温度的增加而非线性下降,提供了一个预测方程.

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Measuring Biomolecular DSC Profiles with Thermolabile Ligands to Rapidly Characterize Folding and Binding Interactions
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Protocol for Measuring the Thermal Properties of a Supercooled Synthetic Sand-water-gas-methane Hydrate Sample
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科学领域:

  • 物理化学 物理化学
  • 聚合物科学 聚合物科学
  • 材料科学 材料科学 材料科学

背景情况:

  • 键 (H键) 在化学和生物学中至关重要.
  • 温度对H键强度的定性影响已知,但定量数据很少.
  • 精确了解H键热力学对于材料设计至关重要.

研究的目的:

  • 量化确定温度与H键内在强度之间的关系.
  • 开发一个经验方程,预测H-键强度作为温度的函数.
  • 推进对不同热条件下的H键行为的基本理解.

主要方法:

  • 在真空中使用了可变温度单分子力谱学 (VT-Vac-SMFS).
  • 作为一个模型聚合物系统,采用聚甲基酸 (poly ((hydroxyethyl methacrylate).
  • 在261 K至363 K的温度范围内测量H键的内在强度.

主要成果:

  • 随着温度的增加,H键的内在强度显著下降.
  • 建立了H键内在强度 (ΔG*) 和温度之间的新型非线性相关性.
  • 提出了经验式方程式: ΔG* = 7.88 - 1.34ln(T - 251.64).

结论:

  • 该研究提供了第一个取决于温度的H键内在强度的定量模型.
  • 导出方程允许通过温度预测和潜在精确控制H键强度.
  • 这项工作将对H键温度依赖的理解从定性转变为定量.