第二到第四位数比率 (2D:4D) 和双极性障碍的认知功能.
Mustafa Nogay Coşkun1, Müge Topcuoğlu2, Betül Keskin3
1Department of Psychiatry, Antalya Atatürk State Hospital, Antalya, Turkey.
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
|April 28, 2025
概括
双极性障碍患者表现出改变的第二到第四位数比率 (2D:4D) 和持续的认知缺陷,即使在缓解期间. 这项研究强调了双相情感障碍患者和健康对照者之间的2D:4D和认知功能的差异.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 内分泌学 在内分泌学.
背景情况:
- 双极性障碍 (BD) 呈现出复杂的情绪,神经心理,免疫和生理变化.
- 在BD患者的认知障碍通常甚至在缓解期内也持续存在.
- 第二到第四数字比率 (2D:4D) 是产前雄激素暴露的潜在标志物,并与各种神经发育状况有关.
研究的目的:
- 研究二至四位数比率 (2D:4D) 与双极性障碍 (BD) 患者的认知功能之间的关系.
- 为了比较2D:4D比率和BD患者在缓解和健康对照之间的认知表现.
主要方法:
- 一项涉及47名BD患者缓解和47名健康志愿者的横截面研究.
- 使用Stroop测试 (ST),威斯康星州卡片排序测试 (WCST) 和Trail Making测试A和B (TMT-A/B) 评估的认知功能.
- 2D:4D比率是用一个数字标尺测量,由一个研究人员进行的一致性测量.
主要成果:
- 与健康对照组相比,BD患者的左侧2D:4D比率显著更高.
- 观察到ST,WCST和TMT-A/B得分的显著差异,BD患者的表现更差.
- 在BD组中,在TMT-A完成时间和右手2D:4D之间发现了弱负相关性.
结论:
- 这项研究揭示了BD患者和健康人之间2D:4D比率的明显差异.
- 即使在缓解期间,BD患者的认知功能仍然受损,这表明长期的神经生物学变化.
- 2D:4D比率可以作为双极性障碍认知变化的潜在生物标志物.
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