患有代谢性,功能障碍相关的脂肪性肝病的患者的肠道微生物群
Lissette Duarte1, Fabien Magne2, Martin Gotteland1,3
1Department of Nutrition.
Current opinion in clinical nutrition and metabolic care
|April 28, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 与肠道细菌失衡有关. 针对肠道微生物群的干预措施有望通过恢复微生物平衡和减少有害代谢物来管理MASLD.
科学领域:
- 胃肠道学和肝病学
- 微生物学 微生物学
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一种普遍的疾病,可能导致严重的肝损伤.
- 肠道微生物群失调和受损的肠道屏障都与MASLD的发病有关.
- 微生物代谢产物具有双重作用,其中一些会加剧肝炎和纤维化,而另一些则具有保护作用.
研究的目的:
- 审查了解肠道微生物群在MASLD中的作用的最新进展.
- 检查以微生物群为重点的干预措施,以改善MASLD的结果.
主要方法:
- 关于肠道微生物群和MASLD的研究的文献综述.
- 微生物代谢物的分析及其对肝脏健康的影响.
- 对针对肠道微生物群的各种治疗干预措施的评估.
主要成果:
- 患有MASLD的患者经常表现出有害代谢物 (例如,乙醇,TMAO) 的增加和有益的代谢物 (例如,SCFA,醇衍生物) 的减少.
- 针对微生物群的干预措施,包括药物,天然化合物,益生菌,特殊饮食和移植,旨在恢复微生物平衡.
- 这些干预措施显示出通过微生物群调节改善肠道透性,肝炎和纤维化方面的潜力.
结论:
- 恢复肠道微生物群的稳态对于管理MASLD至关重要.
- 虽然有希望,但大多数证据来自动物研究,强调需要在MASLD患者中进行更多的临床试验.
- 聚焦微生物群的疗法代表了MASLD管理的潜在替代策略.
相关概念视频
01:24Overview of Lipid Metabolism
789
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
789
01:23Anatomy of the Intestines
70.4K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
70.4K
01:30Liver Physiology
378
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
378
01:24Chronic Pancreatitis I: Introduction
52
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
52
01:24Liver Regeneration
3.2K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.2K
01:27Liver Histology
400
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
Hepatocytes perform a variety of essential functions. They secrete...
400