背中介和腹中介前额叶皮层病变对社会影响和时间折扣有不同的影响
Zhilin Su1, Mona M Garvert2, Lei Zhang1,3,4
1Centre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham, United Kingdom.
PLoS biology
|April 28, 2025
概括
中部前额叶皮层 (mPFC) 的损伤增加了对社会影响的敏感性. 在mPFC中的特定区域,特别是背部部分 (dmPFC),对于社会决策和时间折扣至关重要.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 社会心理学 社会心理学
背景情况:
- 中间前额叶皮层 (mPFC) 参与经济和社会决策.
- 正在进行的辩论质疑功能专业化与mPFC (腹部与背部) 内的梯度对于社会和非社会认知.
研究的目的:
- 调查中部前额叶皮层 (mPFC) 亚区域在对社会影响和时间折扣的敏感性方面的因果作用.
- 在经济决策中区分腹部mPFC (vmPFC) 和背部mPFC (dmPFC) 的功能.
主要方法:
- 使用了大量的焦点mPFC损伤 (N=33),其他病变 (N=17) 和健康对照 (N=71) 个体样本.
- 在了解他人偏好后,进行时间折扣任务,以评估基线偏好和对社会影响的敏感性.
- 采用贝叶斯计算模型和基于voxel的病变症状映射 (VLSM) 来分析折扣和社会影响参数.
主要成果:
- 与对照组相比,mPFC损伤显著增加了对冲动社会影响的敏感性.
- 基于voxel的病变-症状映射确定了背部mPFC (dmPFC,区域9) 对于对社会影响的高度敏感性至关重要 (p <0.025).
- 在vmPFC (区域13,25) 和腹状条纹体的损伤与对即时奖励的偏好有关 (p <0.05).
结论:
- 背部mPFC (dmPFC) 在调节对社会影响的敏感性方面发挥了因果作用.
- 显著的mPFC的腹部区域参与时间折扣和奖励估值.
- 这些发现为基本的社会和认知过程在mPFC内的次区域专业化提供了因果关系证据.
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