肥胖和急性心力衰竭的交叉点:心脏结构和功能以及BMI类别之间的拥堵
Sofie Bøgh-Sørensen1,2, Ross T Campbell3, Brian L Claggett4
1Cardiovascular Non-Invasive Imaging Research Laboratory, The Department of Cardiology, Copenhagen University Hospital - Herlev & Gentofte Hospital, Hellerup, Denmark.
European heart journal. Acute cardiovascular care
|April 28, 2025
概括
肥胖与更大的心脏大小有关,但急性心力衰竭 (AHF) 中类似的拥堵. 与正常体重患者相比,患有AHF的超重和肥胖患者面临着类似的6个月住院或死亡风险.
科学领域:
- 心脏病学 心脏病学
- 肥胖医学 肥胖医学
- 医疗成像医学成像
背景情况:
- 超重和肥胖是心力衰竭 (HF) 的已知的危险因素.
- 肥胖对急性心力衰竭 (AHF) 的具体病理生理影响尚不清楚.
- 了解这些影响对于管理不同体重的AHF患者至关重要.
研究的目的:
- 为了研究心脏结构,功能和充血标志物在成年人住院治疗AHF.
- 为了在不同体质指数 (BMI) 类别中比较这些标志物:正常体重,超重和肥胖.
- 分析基于左心室喷射率 (LVEF) 子组 (HFmrEF/HFpEF与HFrEF) 的结果.
主要方法:
- 心声学和4区肺部超声波用于评估心脏结构,功能和拥堵.
- 患者报告的症状在基线收集.
- 追踪了六个月的结果,包括HF住院和全因死亡率.
主要成果:
- 较高的BMI与年轻的年龄,更多的并发症,先前的HF病史和更糟糕的症状相关.
- 患有HFmrEF/HFpEF的患者年龄较大,女性更常见,BMI较高,高血压和心房动.
- 超重/肥胖患者表现出更大的双心体积/面积和LV质量,与正常体重个体相比,血液动力学拥堵类似,但肺部拥堵较少.
结论:
- 在AHF患者中,超重/肥胖与双心管体积/面积和LV质量增加有关.
- 血液动力学拥堵看起来类似,而肺部拥堵在超重/肥胖个体中不那么明显.
- 在AHF中,HF住院或死亡的6个月风险在所有BMI组中都是可比的.
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