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相关概念视频

Introduction to Epidemiology01:26

Introduction to Epidemiology

543
Epidemiology, known as the cornerstone of public health, involves studying the distribution and determinants of health-related events in defined populations and applying these insights to control health issues. This is essential for understanding how diseases spread, identifying populations at greater risk, and implementing measures to control or prevent outbreaks. Epidemiology addresses not only infectious diseases but also non-communicable conditions like cancer and cardiovascular disease,...
543
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

334
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
334
Infection01:20

Infection

6.4K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
6.4K
Prevalence and Incidence01:08

Prevalence and Incidence

255
In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
255
Liver Histology01:27

Liver Histology

400
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
400
Liver Physiology01:30

Liver Physiology

378
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
378

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相关实验视频

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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

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[E型肝炎:流行病学,病理学和预防]

Nancy León-Janampa1, Denys Brand1, Julien Marlet1

  • 1INSERM U1259 MAVIVHe, Université de Tours et CHRU de Tours, Tours, France.

Medecine sciences : M/S
|April 28, 2025
PubMed
概括

肝炎E病毒 (HEV) 引起急性肝炎,其特定的基因型与流行病和动物传播有关. 虽然HEV通常会自发消失,但在免疫力低下的人群中可能导致慢性感染,这凸显了对卫生和安全水的需求.

科学领域:

  • 肝病学和病毒学.
  • 传染病 流行病学 流行病学
  • 公共卫生和预防医学

背景情况:

  • 肝炎E病毒 (HEV) 是一个重要的全球性病原体,负责急性肝炎.
  • 不同的HEV基因型表现出不同的传播途径和临床表现.
  • 基因型1和2与孕妇的水传播疫情和严重肝炎有关.

研究的目的:

  • 提供关于肝炎E病毒流行病学和临床意义的全面概述.
  • 讨论传播动态,包括口腔便路径和动物感染潜力.
  • 突出预防策略和疫苗开发的现状.

主要方法:

  • 审查关于肝炎E病毒的现有文献.
  • 对有关HEV基因型及其分布的流行病学数据的分析.
  • 临床表现的总结,包括急性,慢性和肝外表现.

主要成果:

  • HEV基因型1和2通过口腔便传播和严重肝炎引起流行病.
  • HEV基因型3和4代表通过食用未煮熟的猪肉传播的动物性疾病.
  • 大多数感染是自我限制的,但慢性肝炎可以在免疫功能低下的患者中发展.

结论:

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  • 有效的预防依赖于改善卫生和获得安全饮用水.
  • 高肝病毒感染的肝外表现是可能的,需要临床考虑.
  • 一种复合的HEV疫苗已经开发出来,正在经过世卫组织的验证.