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SARS-CoV-2 感染对儿童血管系统的长期影响

Dareilena Karaviti¹, Marietta Charakida¹, Dimitra Dimopoulou¹

¹From the Second Department of Pediatrics.

The Pediatric infectious disease journal

|April 28, 2025

概括

长期COVID在儿童中显示内皮细胞激活,但没有持久的动脉变化. 大约四分之一的受感染儿童经历了长期的COVID症状,这表明了独特的童年后COVID条件.

科学领域:

儿科血管健康小儿血管健康
传染病流行病学传染病流行病学
长期的健康结果.

背景情况:

在成年人中,长期的COVID与持续的血管功能障碍有关.
关于COVID-19对儿童的长期血管影响的研究有限.
了解COVID后的儿科血管健康对于长期管理至关重要.

研究的目的:

在COVID-19感染后大约6.8个月的儿童中评估血管健康.
为了比较患有和没有COVID-19病史的儿童之间的血管参数.
在儿童COVID-19幸存者中调查潜在的长期血管后果.

主要方法:

一组223名儿童被分为COVID-19幸存者 (组1) 和健康对照组 (组2).
使用脉冲波速度 (PWV) 和心动脉内膜-介质厚度 (cIMT) 评估了血管健康.
评估了生物标志物,脂质概况和长期COVID症状.

主要成果:

在COVID-19幸存者中观察到可溶性细胞间粘附分子-1水平升高.
脉冲波速度最初在幸存者中较高,但在调整BMI和血压后正常化.
两组之间没有发现动脉内膜介质厚度或炎症标志物的显著差异.
23.6%的COVID-19幸存者报告了长期COVID症状,而对照组的3.8%.

结论:

儿童的COVID-19感染可能导致内皮细胞激活,但没有显著的动脉结构变化.
感染后没有明显的持续性炎症,但长期的COVID症状很常见.
在儿童中,急性COVID-19感染后的病理生理学可能与成年人不同.

关键词:

在 COVID-19 疫情中,动脉内心介质的厚度动脉内心介质的厚度细胞内粘附分子-1 细胞内粘附分子-1 长时间的COVID.儿科儿科儿科脉冲波的速度是脉冲波的速度.

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