雄激素受体表达与瘤免疫景观的关联以及乳腺癌患者的治疗结果
Priya Jayachandran1, Sachin K Deshmukh2, Sharon Wu2
1Division of Medical Oncology, Keck School of Medicine, University of Southern California, Los Angeles, CA.
JCO precision oncology
|April 28, 2025
概括
乳腺癌 (BC) 中的雄激素受体 (AR) 表达表现显示出独特的分子特征,通常与更好的结果有关. 对AR高BC的进一步研究可能会改善晚期疾病的临床试验设计.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
背景情况:
- 雌激素受体 (ER) 在乳腺癌 (BC) 中得到了充分研究.
- 人们对雄激素受体 (AR) 在BC预后和治疗反应中的作用不太了解.
- 在BC亚型中描述AR的临床病理和分子特征至关重要.
研究的目的:
- 描述乳腺癌亚型中AR基因表达的临床病理学和分子特征.
- 调查AR表达水平与瘤分子形状之间的关联.
- 评估AR表达对患者预后和治疗反应的影响.
主要方法:
- 使用下一代DNA测序,全转录组测序和免疫组织化学分析了公元前10,728个样本.
- 根据RNA表达四分位数,将瘤分为AR高和AR低表达群.
- 卡普兰-梅尔估计用于评估与治疗相关的存活率,统计学意义由调整后的P值 (q < .05) 确定.
主要成果:
- 低AR表达与基底类瘤有关.
- 高AR瘤在亚型中表现出像PIK3CA和CDH1这样的基因的突变率增加.
- AR表达差异性影响了免疫场景,但不是对免疫检查点阻塞的反应;高AR瘤通常表现出更长的治疗反应,除了HER2丰富和Luminal B亚型.
结论:
- 高AR乳腺癌呈现出独特的,亚型特定的分子特征.
- 这种特征通常与改善患者的治疗结果有关.
- 进一步探索高AR相关突变和免疫标记物的进一步探索可以为高级BC的分子选择的临床试验设计提供信息.
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