高环境温度与自发流产之间的关联:系统性审查和元分析
Jie Xu1, Haoyi Xu1, Xiaoyu Zhao1
1Department of Obstetrics and Gynecology, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, China.
Ecotoxicology and environmental safety
|April 28, 2025
概括
怀孕期间高温显著增加了自发流产 (SA) 的风险. 在炎热的气候和低收入国家的孕妇特别容易受到这种风险的影响.
科学领域:
- 环境健康 环境健康
- 生殖流行病学 生殖流行病学
- 孕产妇健康 孕产妇健康
背景情况:
- 高环境温度对孕妇构成潜在的风险.
- 之前对高温暴露和自发流产 (SA) 的研究已经产生了不一致的结果.
- 澄清暴露于热量和SA之间的关联对于孕产妇健康指导至关重要.
研究的目的:
- 系统地审查和分析现有的关于高温暴露对自发流产 (SA) 影响的文献.
- 量化与母亲暴露于环境温度升高相关的SA风险.
主要方法:
- 在四个主要数据库 (Web of Science,Cochrane Library,PubMed,EMBASE) 进行了系统的文献搜索,截至2024年6月.
- 在应用预先定义的纳入和排除标准后,包括了9项相关研究.
- 进行了元分析,以计算高温暴露后SA的整体几率比率 (OR).
主要成果:
- 母亲暴露于高环境温度与自发流产风险增加显著相关 (OR:1.09;95% CI:1.02,1.15).
- 亚组分析显示,气候模式有助于观察到的异质性.
- 在炎热地区和低收入国家,孕妇在暴露于热量的情况下,对SA的敏感性增加.
- 对28周前SA重点研究的分析也表明风险增加 (OR: 1.10;95% CI: 1.02,1.18).
结论:
- 怀孕期间高温与自发流产风险增加有关.
- 气候模式在与热暴露相关的SA风险异质性中发挥着重要作用.
- 这项研究为预防SA提供了宝贵的见解,强调了气象因素对怀孕结果的影响.
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