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饮食耐药粉通过恢复微生物平衡和保持肉的肠道屏障功能来防止抗生素后的肠损伤

Simeng Qin¹, Yifeng Zhu², Gang Tian²

¹Institute of Animal Nutrition, Key Laboratory for Animal Disease-Resistance Nutrition of China, Ministry of Education, Sichuan Agricultural University, Chengdu, China; College of Animal Science and Technology, Southwest University, Rongchang, Chongqing, China.

Poultry science

|April 28, 2025

概括

耐药粉 (RS) 补充剂逆转了肉的抗生素诱导的肠道失生症,恢复了微生物多样性并改善了肠道屏障功能. 这种营养策略通过调节肠道微生物群来缓解炎症并促进肠道健康.

科学领域:

动物科学动物科学
微生物学微生物学
营养科学营养科学

背景情况:

抗生素的使用可能会导致肠道失调,减少微生物多样性和损害肠道屏障功能.
众所周知,耐药粉 (RS) 能够调节肠道微生物群并支持宿主健康.

研究的目的:

为了研究饮食RS对肠道微生物群和肠道屏障功能的影响,在肉的抗生素诱导失生症.
评估RS在缓解炎症和恢复抗生素治疗后肠道健康方面的作用.

主要方法:

在肉中建立了抗生素诱导的肠道失生症模型.
在抗生素治疗后的21天内,补充了12%的生土豆粉 (RS) 或基础饮食的饮食.
分析了肠道微生物群的组成,肠道形态,基因表达 (紧密结合,亡) 和血清细胞因子水平.

主要成果:

补充RS恢复了微生物多样性和Firmicutes与Bacteroidetes的比率.
富含RS的有益细菌 (例如,Coprobacter,Faecalibacterium) 和改善的肠的高度和肌肉厚度.
RS增强了有益基因 (GLP-1R,Bcl-2) 的表达,降低了细胞灭绝,并显著降低了阴茎和血清中的促炎细胞因子 (IL-1β,TNF-α).

结论:

饮食RS补充剂有效地减轻了肉的抗生素诱导的肠道失生症.
通过促进肠细胞增殖和减少亡,RS恢复了肠道结构和功能.
RS可以缓解全身炎症,突出其作为治疗营养策略的潜力.

关键词:

抗生素抗生素是一种抗生素.我们的肠道微生物群.炎症炎症是一种炎症.肉的肉可以吃.耐药粉是一种耐药粉.

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