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在心血管代谢综合征中,系统性炎症和恶化的功能之间存在关联
Sunying Wang1, Jilang Zeng2, Yan Chen3
1Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China, 13950489916@163.com.
American journal of nephrology
|April 28, 2025
概括
通过SII和SIRI测量的全身炎症与心血管代谢综合征 (CKM) 患者的功能恶化有关. 在CKM的早期阶段,这种关联更为强烈.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 代谢障碍 代谢障碍 代谢障碍
- 炎症研究 炎症研究
背景情况:
- 心血管-脏-代谢 (CKM) 综合征涉及相互关联的心血管,脏和代谢问题.
- 目前关于CKM综合征的研究主要集中在心血管结果上.
- 慢性全身炎症与CKM综合征中功能下降之间的联系需要进一步调查.
研究的目的:
- 检查CKM综合征患者系统性炎症标志物和恶化功能 (WRF) 之间的关联.
- 为了确定炎症指数是否预测CKM综合征的长期功能变化.
- 在CKM综合征的不同阶段探索炎症和WRF之间的关系.
主要方法:
- 在2014-2021年间对39944名门诊患者的分析中,通过血清肌素增加来定义WRF.
- 后勤回归模型用于评估系统免疫炎症指数 (SII),系统炎症反应指数 (SIRI) 和WRF之间的关联.
- 限制立方线 (RCS) 和细分线性回归用于分析剂量反应关系并确定值.
主要成果:
- 25.9%的患者在第一年内经历了WRF.
- 升高的SII和SIRI水平与CKM综合征中WRF的几率增加显著相关.
- SII (OR: 1.298) 和 SIRI (OR: 1.026) 独立预测了WRF,并观察到剂量反应关系.
结论:
- 在CKM综合征患者中,SII和SIRI都是WRF的显著预测因素.
- 系统性炎症和WRF之间的关联在CKM综合征的早期阶段更为明显.
- 这些发现强调了炎症在CKM综合征进展和功能下降中的作用.
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