被Ecytonucleospora hepatopenaei (EHP) 感染的组织和细胞类型
Yuan Wang1, Shi-Ting Lin2, Ming Zhao1
1East China Sea Fisheries Research Institute, China Academy of Fishery Sciences, Shanghai 200090, China.
Journal of invertebrate pathology
|April 28, 2025
概括
乙核核 (Ecytonucleospora hepatopenaei,简称EHP) 感染,主要向消化系统的上皮细胞,如肝. 这项研究证实EPH不会导致的全身感染.
科学领域:
- 水产养殖病理学 水产养殖病理学
- 海洋生物学 海洋生物学
- 无脊椎动物动物学
背景情况:
- 甲状腺核 (Ecytonucleospora hepatopenaei,简称EHP) 是一种显著的微型菌病原体,在全球范围内影响养殖.
- 肝胰腺是主要的已知点,但EPH的全组织和细胞热带性,特别是在严重的感染中,尚未完全理解.
- 了解EHP热带性对于养殖中的疾病管理至关重要.
研究的目的:
- 在严重感染的Penaeus vannamei.中全面调查EPH感染的组织病理学.
- 为了确定EHP在宿主中的精确组织和细胞热带性.
- 评估EPH引起全身感染的可能性.
主要方法:
- 对严重感染的Penaeus vannamei.的组织进行细胞病理学检查.
- 超结构病理学分析细胞感染.
- 感染严重程度与肝大脑中观察到的病变的相关性.
主要成果:
- 在消化系统内发现了EHP子,但不在非消化组织 (,心脏,生殖腺等) 中. ) 的情况.
- 感染仅限于肝,中肠和中肠白肠的上皮细胞,这些区域缺乏素.
- 特定的肝细胞类型 (R,F,B,E,M细胞) 被确定为受感染的.
- 尽管存在子,食道,胃和后肠的上皮细胞仍然不受影响,这是由于质层.
结论:
- EHP表现出严格的细胞热带性,专门感染的消化系统的特定上皮细胞.
- 在Penaeus vannamei中,EHP不会引起系统性感染,即使是在严重的疾病条件下.
- 在某些消化道部分存在质层,可以防止EHP感染.
相关概念视频
01:15Diversity of Protists I
Excavata is a diverse group of protists that includes both chemoorganotrophic and phototrophic species, with some thriving in anaerobic environments. Among the key groups within Excavata are diplomonads and parabasalids, which are flagellated protists that lack mitochondria and chloroplasts. These microorganisms typically inhabit anoxic environments, such as the intestines of animals, where they exist either symbiotically or as parasites, relying on fermentation for energy production. Some...
01:25Hepatitis
Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
01:28Viral Hepatitis I: Introduction
Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
01:29Hepatic Encephalopathy
DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...