相关实验视频

Updated: May 5, 2026

Development of an In Vitro Assay to Evaluate Contractile Function of Mesenchymal Cells that Underwent Epithelial-Mesenchymal Transition

Development of an In Vitro Assay to Evaluate Contractile Function of Mesenchymal Cells that Underwent Epithelial-Mesenchymal Transition

Published on: June 10, 2016

基底和AT2细胞通过EMT促进IPF-肺癌的同时发生:单细胞分析

Cheng Ren¹, Yawan Zi², Xiaobin Zhang³

¹Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, Chongqing, 400016, China; Department of Respiratory and Critical Care Medicine, Chongqing University Fuling Hospital, Fuling, Chongqing, 408000, China.

Experimental cell research

|April 28, 2025

概括

异形性肺纤维化 (IPF) 和肺癌 (LCA) 具有共同的途径. 基底细胞,膜2型细胞和巨细胞的分子变化及其相互作用在IPF和LCA的共患病发病过程中至关重要.

科学领域:

肺部医学肺部医学
在瘤学瘤学.
细胞生物学细胞生物学

背景情况:

异形性肺纤维化 (IPF) 是一种渐进的肺部疾病.
IPF患者患肺癌 (LCA) 的风险增加,预后较差.

研究的目的:

阐明IPF和LCA同时发生的共享病理机制和分子途径.
为了确定关键的细胞组件和相互作用,涉及到常见的病变发生.

主要方法:

对基因表达综合 (GEO) 数据的单细胞分析.
在患者组织样本上进行免疫光色彩定位.

主要成果:

基底细胞 (BCs) 和膜2型细胞 (AT2细胞) 呈现出与IPF和LCA相关的改变分子通路.
在细胞相互作用中确定了特定的基因 (KRT17,S100A14,WFDC2,KRT19) 和轴 (FN1-WNT,CYBA-ERK1/2,JUN/SOD2-糖解).
通过CYBA-ERK1/2轴和JUN/SOD2-糖解轴的M2巨分极的基础巨相互作用有助于共同发病.

结论:

在BCs,AT2细胞和巨细胞中发生的分子变化对于IPF和LCA病原发生至关重要.
这些细胞类型之间的细胞间通信对于这两种疾病的进展至关重要.

关键词:

基底细胞是一种基底细胞.在IPF中,IPF是IPF.肺癌是一种肺癌.一个单细胞分析.2型膜上皮细胞.

更多相关视频

The Establishment of a Lung Colonization Assay for Circulating Tumor Cell Visualization in Lung Tissues

The Establishment of a Lung Colonization Assay for Circulating Tumor Cell Visualization in Lung Tissues

Published on: June 16, 2018

Assessment of Mitochondrial Health in Cancer-Associated Fibroblasts Isolated from 3D Multicellular Lung Tumor Spheroids

Assessment of Mitochondrial Health in Cancer-Associated Fibroblasts Isolated from 3D Multicellular Lung Tumor Spheroids

Published on: October 21, 2022

相关概念视频

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.