老年住院患者的虚弱和药物负担指数之间的关系
Yukako Morisaki1, Misuzu Takashima1, Ayako Maeda-Minami2
1Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Japan.
In vivo (Athens, Greece)
|April 28, 2025
概括
患有虚弱的老年住院患者使用药物负担指数 (DBI) 药物的风险较低. 这表明,在超级老龄化社会中,对脆弱个体的处方应该谨慎.
科学领域:
- 老年医学 老年医学
- 临床药理学 临床药理学
- 药学流行病学 药学流行病学
背景情况:
- 在脆弱的老年人中了解抗胆固醇和镇静药物的使用对于超级老龄化社会中适当的医疗干预至关重要.
- 药物负担指数 (DBI) 药物是由于其抗胆固醇和镇静作用而引起关注的.
- 这项研究调查了住院老年患者的虚弱和DBI药物使用之间的关联.
研究的目的:
- 为了评估虚弱与处方药物负担指数 (DBI) 药物之间的关联.
- 为适当的医疗干预提供信息,并促进老年人适当的药物使用.
- 分析虚弱与非虚弱住院的老年患者的药物使用模式.
主要方法:
- 卡梅达医疗中心住院患者的横截面研究 (2016年10月至2017年10月).
- 根据巴特尔指数 (<90) 或迷你精神状态检查 (<18) 定义的脆弱性.
- 根据患者背景因素调整后的后勤回归分析,以在不同组之间比较DBI药物使用.
主要成果:
- 药物负担指数 (DBI) 吸毒者的比例在脆弱群体中明显低于非脆弱群体.
- 在脆弱组中,DBI药物使用的调整后几率比为0.32 (95% CI:0.24-0.42,p<0.001).
- 这表明,在脆弱的住院老年患者中,DBI药物使用的可能性降低了.
结论:
- 在日本,患有虚弱的住院老年患者使用药物负担指数 (DBI) 药物的风险可能较低.
- 脆弱的老年患者可能会更谨慎地处方药物.
- 临床实践应考虑患者的脆弱性和背景因素来决定老年人的药物治疗.
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