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Assessment of Social Interaction Behaviors
Published on: February 25, 2011
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在老鼠帮助行为中,个体变化的神经和行为相关性:社会归属和催产素受体的作用
R Hazani1,2,3, J M Breton4, E Trachtenberg5,6
1Psychology Department, Bar-Ilan University, Ramat Gan, Israel, 5290002.
概括
帮助别人处于困境的老鼠表现出更多的社会行为,并在核中具有更高的催产素受体水平. 亲社会行为与与同理心和奖励相关的大脑区域的活动有关.
科学领域:
- 神经科学是一个神经科学.
- 伦理学 伦理学 伦理学
- 行为生物学 行为生物学
背景情况:
- 亲社会行为,帮助别人处于困境,在社会物种中观察到.
- 在帮助行为方面存在个体差异,有些老鼠始终在帮助 (开放者),而另一些老鼠则没有 (非开放者).
研究的目的:
- 为了识别那些帮助痛苦的同类 (开放者) 和那些不 (非开放者) 的老鼠之间的行为和神经差异.
- 探索大鼠亲社会行为的神经支柱.
主要方法:
- 用老鼠的帮助行为测试来分类动物为打开者或非打开者.
- 使用行为观察,催产素受体mRNA水平分析,转录途径分析,化学遗传学操纵和c-Fos表达用于大脑全神经活动.
- 在雄性和雌性打开鼠和非打开鼠之间进行了比较.
主要成果:
- 开放者比非开放者表现出明显更多的社会附属行为.
- 较高的催产素受体mRNA水平在开放者的核内 (NAc) 中发现.
- 整个大脑的神经活动分析显示,亲社会大脑区域内开门器的活性增加,包括胰岛,体感,带膜和额叶皮层,以及NAc.
结论:
- 在老鼠中,亲社会行为与更高的附属行为和特定大脑区域的独特神经活动模式有关.
- 这些发现表明,亲社会行为可以通过附属倾向和神经网络活动来预测.
- 这项研究为研究亲社会行为的因果机制提供了潜在的神经点.
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