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药物释放式隐形眼镜及其应用于疾病表现的应用
Chau-Minh Phan1, David Wulff1, Minal Thacker2
1Centre for Ocular Research and Education, School of Optometry & Vision Science, University of Waterloo, Waterloo, Canada.
Clinical & experimental optometry
|April 28, 2025
概括
与眼滴相比,隐形眼镜药物递送系统提供了较好的眼部生物可用性. 本综述探讨了开发这些创新型透镜的挑战和进展,用于治疗眼部感染,干眼,过敏和绿眼病.
科学领域:
- 眼科和制药科学 眼科和制药科学
- 生物材料和药物输送
背景情况:
- 传统的眼滴具有较低的眼部生物可用性,只有不到7%的药物到达目标前段组织.
- 隐形眼镜为眼部药物输送提供了一个有希望的替代品,提高了眼睛表面的药物停留时间和生物可用性.
研究的目的:
- 审查开发用于药物输送的隐形眼镜的考虑因素和挑战.
- 探索药物释放式隐形眼镜在四大眼部疾病类别中的应用:前部部位感染,干眼疾病,眼部过敏和玻璃眼.
- 通过隐形眼镜提供对治疗需求和眼部药物输送进展的见解.
主要方法:
- 审查有关隐形眼镜药物递送系统的现有文献.
- 对特定眼部疾病的治疗需求的分析.
- 检查技术方面,包括镜头特性,药物释放动力学和安全性.
主要成果:
- 释放药物的隐形眼镜提供了一种可行的策略,以克服传统眼药的局限性.
- 针对不同的眼睛疾病需要量身定制的方法,解决镜片材料,药物加载和释放配置文件.
- 商业上可用的蒂芬烟酸释放透镜的开发证明了这项技术的实际可行性.
结论:
- 隐形眼镜药物递送系统代表了眼科治疗学的重大进步.
- 需要进一步的研究和开发来完善镜片的特性,优化药物释放,并确保广泛临床应用的长期安全性.
- 这种创新方法具有改善各种眼部疾病管理的巨大潜力.
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